Condition

Chronic Coronary Syndrome clinical trials and research

• 33Clinical trials
• 17Countries

Newest Chronic Coronary Syndrome clinical trials

All recruiting trials (33)

• Common femoral vein-to-artery diameter ratio to detect elevated LVEDP

  Researchers test whether the ratio of the common femoral vein to artery diameters, measured by ultrasound, can flag elevated LV end-diastolic pressure in patients having coronary angiography.

  Recruiting Burapha University · Chon Buri · NCT07866859

• Aspirin 50 mg vs 100 mg with a P2Y12 inhibitor after PCI

  This trial tests whether a 50 mg daily aspirin dose, when used with a P2Y12 inhibitor after PCI, works as well as 100 mg with similar safety for people staying on DAPT for 12 months.

  Recruiting Jilin University · Changchun, Jilin · NCT07846462

• See if stopping long-term aspirin is as good as continuing it in older adults with stable ischemic heart disease

  In adults 65 and older with stable ischemic heart disease, this trial tests whether stopping daily low-dose aspirin is not worse than continuing it.

  Recruiting at 2 sites Phase 4 Odense University Hospital · Copenhagen and 1 other locations · NCT07795398

• IVUS-Guided Left Main Stenting: IVUS-Guided vs Trained-Eye Approach

  This trial tests whether using IVUS to guide left main bifurcation stenting is as good as using an angiography-driven, experience-based approach by an IVUS-savvy operator.

  Recruiting Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health · Saint Petersburg · NCT07711106

• Can CZT-SPECT/CT quantify myocardial tracer uptake to match PET measurements in coronary artery disease?

  This study tests whether CZT-SPECT/CT can quantify heart blood flow at rest and stress and see if the results align with PET measurements for people with coronary artery disease.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans, Loiret · NCT07708805

• Ultrasound vs CT calcium scoring to reclassify symptomatic chest pain

  This study tests whether carotid ultrasound can reclassify risk in adults with chest pain and suspected chronic coronary syndrome, compared with the CT calcium score.

  Recruiting London North West Healthcare NHS Trust · Harrow · NCT07696533

• Advanced invasive diagnosis for post-PCI angina in patients referred for coronary angiography

  This study tests a specialized invasive approach to find the cause of angina in people who previously had PCI and are now referred for coronary angiography.

  Recruiting at 5 sites Fundacion Investigacion Interhospitalaria Cardiovascular · Leganés, Madrid and 4 other locations · NCT07638137

• Echo-AVCS: Drawing AI-powered clues from heart scans to confirm severe aortic stenosis

  This study tests an AI-based echocardiography score to help confirm severe aortic stenosis in adults who are also getting CT calcium scoring.

  Recruiting at 4 sites Azienda Ospedaliera "Sant'Andrea" · Bologna and 4 other locations · NCT07620925

• Zastaprazan's effect on clopidogrel platelet response after PCI

  This test will see if zastaprazan, compared with rabeprazole, changes how clopidogrel controls platelets in people on dual antiplatelet therapy after PCI.

  Recruiting Phase 4 Yonsei University · Yongin-si, Gyeonggi-do · NCT07471867

• AI-driven Medipixel fractional flow reserve to guide PCI

  This test checks whether an AI-based, angiography-derived Medipixel FFR method can guide PCI as safely and effectively as standard invasive pressure-wire FFR in adults with coronary artery disease.

  Recruiting at 23 sites Samsung Medical Center · Seoul, Select State and 22 other locations · NCT07329699

• Microplastics and nanoplastics in people with chronic coronary syndromes

  This study will test whether tiny plastic particles (micro- and nanoplastics) can be detected in the coronary blood of adults with suspected or known chronic coronary syndromes who are having coronary CT and invasive angiography.

  Recruiting at 2 sites Azienda Ospedaliera "Sant'Andrea" · Caserta and 5 other locations · NCT07291609

• High- vs low-dose aspirin and aspirin plus prasugrel after coronary artery bypass grafting

  This trial will test whether adding prasugrel to low-dose aspirin or using high-dose aspirin works better than low-dose aspirin alone to prevent graft failure in adults with stable coronary artery disease after coronary bypass surgery.

  Recruiting at 8 sites Phase 3 Dolnośląskie Centrum Chorób Serca im.prof. Zbigniewa Religi MEDINET Sp. z o.o. · Bialystok and 17 other locations · NCT07195149

• FAPI PET/CT to predict adverse cardiac events after PCI for chronic total occlusion

  This will test whether FAPI PET/CT scans done before PCI can help predict major heart problems within 12 months in adults with chronic total coronary occlusion.

  Recruiting Beijing Chao Yang Hospital · Beijing, Beijing Municipality · NCT07020858

• Plasma NT‑proBNP and the extent of coronary artery disease

  This project tests whether a blood NT‑proBNP level can indicate how much coronary artery disease someone referred for elective coronary angiography has.

  Recruiting IRCCS Ospedale San Raffaele · Milan, Italy and 1 other locations · NCT07013344

• Assessing non-significant coronary artery disease lesions using advanced imaging techniques

  This study is trying to see if advanced imaging techniques can help doctors better understand and manage patients with heart artery blockages that might not be serious.

  Recruiting Shiraz University of Medical Sciences · Shiraz, Fars · NCT06979427

• Measuring Tryptase Levels in Patients with Stable Coronary Artery Disease

  This study is testing if measuring tryptase levels in people with stable coronary artery disease can help predict their risk of having serious heart problems in the future.

  Recruiting at 2 sites University of Thessaly · Athens, Attica and 1 other locations · NCT06958016

• Analyzing Blood Changes in Patients with Acute Coronary Syndrome

  This study looks at blood samples from patients with acute coronary syndrome to see how their blood factors differ from those without heart disease, hoping to find clues about the condition's outlook.

  Recruiting Second Affiliated Hospital of Wenzhou Medical University · Lishui, Zhejiang · NCT06955143

• Intensive versus standard cholesterol lowering to slow coronary plaque in young and middle-aged adults with chronic coronary syndrome

  This trial will test whether more intensive cholesterol lowering (LDL-C <1.0 mmol/L) compared with guideline-level lowering (LDL-C <1.8 mmol/L) can slow or reverse coronary plaque in adults 18–60 with chronic coronary syndrome and a 50–70% lesion on CCTA.

  Recruiting Guangdong Provincial People's Hospital · Chongqing, Chongqing Municipality and 6 other locations · NCT06896708

• Identifying biomarkers for high-risk coronary plaques

  This study is trying to find new blood markers that can help predict dangerous heart plaque in patients with chronic heart issues or certain types of heart attacks.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06793787

• Evaluating adherence to ESC guidelines for Chronic Coronary Syndrome

  This study looks at how well doctors are following the latest guidelines for treating chronic coronary syndrome in adults to see what helps or hinders their care.

  Recruiting European Society of Cardiology · Yerevan · NCT06748924

• Comparing drug-coated balloons and drug-eluting stents for patients with high bleeding risk and chronic coronary syndrome

  This study is testing whether using drug-coated balloons instead of drug-eluting stents can help patients with chronic coronary syndrome who are at high risk for bleeding, while also looking at how long they need to take blood-thinning medicine after the procedure.

  Recruiting at 18 sites Samsung Medical Center · Ansan and 17 other locations · NCT06742931

• Comparing orbital atherectomy and intravascular lithotripsy for calcified coronary nodules

  This pilot trial will see if orbital atherectomy or intravascular lithotripsy better prepares OCT-identified calcified coronary nodules for stent placement in adults with coronary artery disease.

  Recruiting at 6 sites Spanish Society of Cardiology · Alicante, Alicante and 5 other locations · NCT06736665

• Healthy Nordic diet's effects on heart disease

  This study is testing if following a Healthy Nordic diet can help people with coronary heart disease improve their heart health over 18 months.

  Recruiting Uppsala University · Uppsala · NCT06701968

• Investigating different doses of adenosine for heart imaging

  This study tests whether different doses of adenosine can improve heart imaging for people suspected of having chronic coronary syndrome.

  Recruiting Phase 4 Region Skane · Lund · NCT06578234

• Heart registry for patients after coronary interventions in South East Netherlands

  This study is creating a registry to help doctors better understand and treat patients in South East Netherlands who have had heart procedures, aiming to reduce their risk of future heart problems.

  Recruiting at 4 sites Radboud University Medical Center · Heerlen, Limburg and 3 other locations · NCT06512493

• Evaluating Imaging Techniques for Heart Disease in Patients with Chronic Coronary Syndrome

  This study is testing how well two imaging techniques, FFR and OCT, can help people with chronic coronary syndrome and narrowed arteries understand their heart health better.

  Recruiting Medical University of Warsaw · Warsaw · NCT06261866

• Evaluating the impact of angiography-based FFR after heart procedures

  This study is trying to see if measuring blood flow in heart arteries after a heart procedure can help predict serious heart problems and improve patients' quality of life.

  Recruiting Medical University of Warsaw · Warsaw · NCT06255678

• Comparing stress echocardiography and CT coronary angiography for chronic coronary syndrome

  This study is testing whether a combination of stress echocardiography and carotid ultrasound works better than regular CT scans for diagnosing heart problems in adults with chronic coronary syndrome.

  Recruiting London North West Healthcare NHS Trust · Harrow, Middx · NCT06185530

• Yangxinshi tablets for improving exercise capacity in chronic coronary syndrome patients

  This study is testing if adding Yangxinshi tablets to standard treatment can help people with chronic coronary syndrome walk farther and improve their exercise ability.

  Recruiting at 6 sites Phase 4 Shandong First Medical University · Chongqing, Chongqing Municipality and 31 other locations · NCT06171061

• Assessing treatment strategies for chronic coronary syndrome

  This study is testing whether getting heart surgery sooner or sticking with medication helps people with chronic coronary syndrome feel better after three months.

  Recruiting Gødstrup Hospital · Herning, Central Jutland · NCT05865600

• Using SGLT2 inhibitors to prevent heart rhythm issues and kidney injury before heart surgery

  This study is testing if a medication called dapagliflozin can help prevent heart rhythm problems and kidney issues in patients with chronic coronary syndrome who are about to have heart surgery.

  Recruiting at 4 sites Phase 3 Region Örebro County · Brno and 7 other locations · NCT05852704

• Comparing drug eluting balloons to stents for treating coronary lesions

  This study is testing whether a special balloon treatment works better than standard stents for people with long-lasting heart artery blockages.

  Recruiting Phase 4 Cardiocentro Ticino · Lugano · NCT05674630

• Evaluating strategies to reduce unnecessary heart imaging tests for stable chest pain

  This study is testing two different ways to see if they can help doctors better identify patients with stable chest pain who don’t need unnecessary heart imaging tests.

  Recruiting at 4 sites Tianjin Chest Hospital · Beijing, Beijing Municipality and 3 other locations · NCT05640752

Related topics

Quick answers

How many Chronic Coronary Syndrome clinical trials are recruiting right now?

33, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in China (7 trials), Poland (3 trials), Italy (3 trials), Sweden (3 trials), Denmark (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 5, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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