Investigating how a protein called Junctophilin-2 is affected in heart disease
Junctophilin-2 cleavage in ischemic heart disease
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10804645
This study is looking at how a protein called Junctophilin-2 (JPH2) is affected in heart disease, specifically how it gets broken down by an enzyme, which might change how heart cells work and lead to heart failure, with the hope that this research will help find new treatments for people with heart problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10804645 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of Junctophilin-2 (JPH2) in ischemic heart disease, a condition that significantly impacts heart function. The study aims to explore how the enzyme calpain cleaves JPH2, leading to changes in heart cell function and potentially contributing to heart failure. By examining the molecular mechanisms involved, the research seeks to uncover how the resulting JPH2 fragments affect calcium signaling and heart muscle remodeling. Patients may benefit from insights that could lead to new therapeutic strategies for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ischemic heart disease or those at risk for heart failure.
Not a fit: Patients with non-ischemic heart conditions or those without heart disease may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and outcomes for patients with ischemic heart disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of JPH2 in heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEHRENS, XANDER H.T. — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: WEHRENS, XANDER H.T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.