Condition

Inflammatory Response clinical trials and research

• 14Clinical trials
• 32NIH research projects
• 11Countries

Newest Inflammatory Response clinical trials

All recruiting trials (14)

• Velocity-based resistance training to reduce inflammation in older adults

  This program will test whether different amounts of velocity-based resistance training can lower inflammation in adults aged 60–75 who do not regularly do resistance exercise.

  Recruiting National Taipei University · Taipei · NCT07566832

• Effects of hop compounds on the immune system in overweight individuals

  This study tests whether compounds from hops can help boost the immune system in overweight people who might be at risk for metabolic diseases.

  Recruiting University of Vienna · Vienna · NCT06745102

• Exploring the effects of Daoist standing meditation on well-being

  This study is testing whether practicing Daoist standing meditation can improve well-being and reduce stress compared to doing a simple wall squat.

  Recruiting University of North Carolina, Charlotte · Charlotte, North Carolina · NCT06573034

• How exercise affects the brain and inflammation in depression

  This project tests whether adding a structured exercise program to standard antidepressant treatment helps people with moderate major depressive disorder and whether it reduces inflammation and changes brain markers.

  Recruiting at 5 sites Fundación de Investigación Biomédica - Hospital Universitario de La Princesa · Alcalá de Henares, Madrid and 4 other locations · NCT06450704

• Monitoring severe COVID-19 infections in children in Israel and England

  This study is trying to track how severe COVID-19 affects children under 16 in emergency departments in Israel and the UK to better understand the illness and its complications.

  Recruiting at 6 sites Hadassah Medical Organization · Afula and 5 other locations · NCT06434701

• Influenza vaccination's effect on heart inflammation after a heart attack

  This study is testing if getting a flu shot after a heart attack can help reduce inflammation in the heart for patients who have just had a procedure to open blocked arteries.

  Recruiting at 3 sites Phase 4 Region Örebro County · Aarhus and 2 other locations · NCT06336317

• Effects of hop compounds on the immune system

  This study tests whether hop compounds can affect the immune system in healthy people over a six-hour period.

  Recruiting University of Vienna · Vienna · NCT06286644

• Impact of switching from menthol to non-menthol cigarettes on inflammation and smoking behavior

  This study is testing how switching from menthol to non-menthol cigarettes affects inflammation and smoking habits in people who usually smoke menthols.

  Recruiting Rosalind Franklin University of Medicine and Science · North Chicago, Illinois · NCT06232447

• Colchicine's effect on inflammation during cardiac surgery

  This study is testing if colchicine can help reduce inflammation and improve recovery for people aged 50 to 80 who are having heart surgery.

  Recruiting Phase 3 The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT06118034

• How menstrual-cycle hormone changes affect response to eccentric leg exercise

  This project will test whether normal menstrual-cycle changes in estrogen and progesterone change how women feel before and after eccentric leg exercise and how quickly they recover.

  Recruiting University of Southern California · Los Angeles, California · NCT05934708

• Can DNase 1 help reduce inflammation after an ischemic stroke?

  Researchers are testing if giving DNase 1 to adults within 12 hours of ischemic stroke can lower the body’s inflammatory response compared with a placebo.

  Recruiting at 3 sites Phase 2 Ludwig-Maximilians - University of Munich · Munich, Bavaria and 4 other locations · NCT05880524

• Memory CD8+ T Cells and Sepsis Severity: An Observational Study at a Single Center

  This study will observe adults with sepsis to see if certain memory CD8+ T cells correlate with how severe the illness and risk of death are.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT05875740

• Exploring the link between body composition and pain in spinal cord injury

  This study is testing how different types of meals affect pain and inflammation in people with spinal cord injuries to see if body composition plays a role.

  Recruiting University of Miami · Coral Gables, Florida · NCT05459207

• Using tranexamic acid to reduce inflammation in traumatic brain injury

  This study is testing if giving tranexamic acid to patients with traumatic brain injury can help reduce inflammation and improve their recovery.

  Recruiting Phase 3 Assiut University · Asyut, Assuit · NCT05323149

NIH-funded research (32)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• SSRI use during pregnancy: effects on placental blood flow and inflammation

  This grant studies how antidepressants (SSRIs) used during pregnancy might affect the placenta and inflammation, and whether a 5-HT2 receptor blocker could mitigate any negative effects.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11608163

• Understanding how skin inflammation is controlled to help conditions like atopic dermatitis

  A study at UC San Diego investigates how skin cells regulate inflammation to prevent prolonged skin redness and injury.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11421881

• Estrogen and neutrophil function in lung disease among adults with CF and bronchiectasis

  This grant tests how estrogen may change neutrophil behavior and lung inflammation in adults with cystic fibrosis or non-CF bronchiectasis to explain why women often have worse outcomes.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11419822

• Targeting inflammation in age-related macular degeneration

  Aims to understand how inflammation drives age-related macular degeneration in people and explore new targets to slow or stop vision loss.

  NIH research Yale University · New Haven, United States · NIH-11418964

• T-Cell Signals in Neonatal Heart Regeneration

  This project explores how a specific immune pathway involving CD4+ T helper 2 cells may help the neonatal heart repair itself after injury in mouse models, with potential implications for human heart healing.

  NIH research University of Arizona · Tucson, United States · NIH-11417875

• Monocyte-derived alveolar macrophages fuel lung inflammation after ozone exposure

  This study looks at how certain immune cells in the lungs called monocyte-derived alveolar macrophages respond to ozone exposure and worsen lung inflammation, especially after prior lung injury.

  NIH research Duke University · Durham, United States · NIH-11348245

• Understanding how a brain barrier molecule affects neutrophil-driven brain inflammation in Alzheimer’s

  A patient-focused look at how a molecule that helps immune cells stick to brain blood vessels might influence inflammation and progression in Alzheimer’s disease.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11322641

• Reducing skin inflammation at insulin pump sites

  New methods to make insulin-pump infusion sites less inflamed for people with diabetes.

  NIH research Wayne State University · Detroit, United States · NIH-11318895

• Inflammation after organ transplant

  Looking at how prior immune memory cells and tissue damage from low blood flow cause inflammation that can harm transplanted organs in people receiving solid organ transplants.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11232325

• How estrogen affects lung inflammation and infections in cystic fibrosis and bronchiectasis

  This project looks at whether estrogen changes how neutrophils (a type of white blood cell) behave and makes lung infections and flare-ups worse for people, especially females, with cystic fibrosis or non-CF bronchiectasis.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11193923

• Reducing harmful inflammation in wet age-related macular degeneration

  This project looks for ways to block damaging immune inflammation in people with neovascular (wet) age-related macular degeneration to help protect their vision.

  NIH research Yale University · New Haven, United States · NIH-11172498

• Understanding how immune cells contribute to lung injury

  This research explores how certain immune cells called neutrophils cause lung damage in conditions like acute lung injury and ARDS, aiming to find new ways to protect the lungs.

  NIH research University of California-Irvine · Irvine, United States · NIH-11171714

• Understanding the immune response to COVID-19

  This study is looking at how different people's bodies react to the COVID-19 virus, especially how their immune systems respond, and it's for anyone with COVID-19 or healthcare workers, as it aims to learn more about how the illness progresses and what helps people recover.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11171035

• Investigating how platelets and blood factors affect inflammation after heart valve replacement

  This study is looking at how blood platelets and other factors affect recovery after a heart procedure called TAVR, which helps people with a narrowed aortic valve, and it aims to find ways to make the procedure safer and more effective for patients who can't have regular surgery.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11136778

• Investigating how certain immune cells respond to lung damage from ozone exposure

  This study is looking at how certain immune cells in the lungs react to damage from ozone, especially in people who have had previous lung infections, to help find better ways to treat breathing problems caused by air pollution.

  NIH research Duke University · Durham, United States · NIH-11121823

• Controlling Inflammation by Targeting a Key Receptor

  This work explores new ways to manage inflammation by focusing on a specific protein called CXCR3, which plays a big role in how our immune system responds.

  NIH research Duke University · Durham, United States · NIH-11117066

• Understanding how a specific molecule affects inflammation in Alzheimer's disease

  This study is looking at how a protein called JAM-A affects inflammation in Alzheimer's disease by examining how certain white blood cells behave, with the hope of finding new ways to reduce inflammation and support brain health for people with Alzheimer's.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11087579

• Understanding how DNMT3A mutations affect inflammation in older adults

  This study is looking at how certain changes in blood cells, which are more common in people over 60, might increase inflammation and health risks like cancer and heart disease, with the goal of finding new ways to help manage these issues.

  NIH research University of California-Irvine · Irvine, United States · NIH-11077823

• Investigating how environmental factors affect brain health and Alzheimer's disease.

  This study is looking at how things in our environment, like harmful substances, might affect the brain and contribute to Alzheimer's disease, with the hope of finding new ways to prevent or treat the condition for those affected.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11075805

• Improving insulin infusion devices to reduce inflammation and extend use.

  This study is looking at ways to make insulin delivery devices better for people with diabetes by figuring out how to reduce skin irritation caused by certain preservatives in insulin, so you can wear your infusion sets longer and manage your diabetes more easily.

  NIH research Wayne State University · Detroit, United States · NIH-11049078

• Investigating the effects of different light wavelengths on dental materials and inflammation

  This study is looking at how different colors of light used in dental treatments can affect inflammation in your mouth, with the hope of finding safer ways to help your teeth heal while keeping any discomfort to a minimum.

  NIH research University of Florida · Gainesville, United States · NIH-11032477

• Investigating how certain microRNAs affect fetal inflammation during pregnancy

  This study is looking at how infections in pregnant women might cause inflammation in their babies, and it aims to find out how certain tiny molecules in the body can affect the baby's immune system and health, which could help prevent problems like preterm birth.

  NIH research Yale University · New Haven, United States · NIH-11032217

• How acetate affects blood cell development and inflammation

  This study is looking at how a substance called acetate, which increases when we have inflammation, affects the behavior of blood-forming cells, and it aims to help people understand how diet and inflammation might influence blood health and related issues.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10996111

• How estrogen affects immune response and lung inflammation in certain lung diseases

  This study is looking at how estrogen affects immune cells and lung inflammation in women with Cystic Fibrosis and nonCF bronchiectasis, to understand why they often have worse health than men, especially when estrogen levels are high, and to find ways to help improve their lung health.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10991292

• Investigating inflammation in age-related macular degeneration

  This study is looking at how inflammation affects age-related macular degeneration (AMD), a common cause of vision loss in older people, to find new ways to treat it by examining eye tissue and immune cells.

  NIH research Yale University · New Haven, United States · NIH-10911185

• Investigating how hHv1 channels in neutrophils affect lung inflammation and injury

  This study is looking at how a specific channel in white blood cells affects lung damage during serious conditions like acute lung injury and ARDS, and it aims to see if blocking this channel can help reduce inflammation and improve breathing for people with these issues.

  NIH research University of California-Irvine · Irvine, United States · NIH-10867338

• Investigating how platelets and blood factors affect inflammation after heart valve replacement

  This study is looking at how certain blood factors affect recovery after a less invasive heart procedure called TAVR, which is used to treat severe aortic stenosis, to help doctors find better ways to prevent complications and improve patient outcomes.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-10864053

• Understanding the immune response to SARS-CoV-2 in diverse populations

  This study is looking at how different groups of people, including COVID-19 patients and healthcare workers, react to the virus to better understand how the illness progresses and how the body fights it, all to help improve care and recovery for everyone affected by COVID-19.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10855003

• How vaccines affect heart health and inflammation

  This study is looking at how vaccines might affect heart health in people who already have heart problems, by checking how their immune systems respond to the vaccines and if that changes their risk of heart issues.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10815560

• Using non-coding RNAs to predict HPV status and outcomes in oropharyngeal cancer patients

  This study is looking at how certain types of RNA in your blood can help us understand your immune response to HPV if you have oropharyngeal cancer, which could lead to better treatment options for you based on your specific needs.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10747865

• Understanding how different people respond to COVID-19 vaccines

  This study is looking at how the immune system reacts to COVID-19 in people with weakened immune systems, and it aims to use this information to improve vaccine and booster recommendations to keep everyone healthier.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10706736

• Understanding how different people respond to COVID-19

  This study is looking at how different people's immune systems respond to the COVID-19 virus, especially those who might get sicker, to help find better ways to treat and prevent the illness, and it involves tracking the health of patients and healthcare workers over time.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10688386

Related topics

Quick answers

How many Inflammatory Response clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (4 trials), China (2 trials), Austria (2 trials), Israel (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 4: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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