Investigating how platelets and blood factors affect inflammation after heart valve replacement
Official title: Platelets and Hemostatic Factors as Facilitators of the Inflammatory Response Following Transcatheter Aortic Valve Replacement
Funded at University of Cincinnati · NIH-10864053 · Data updated 2026-11-12
This study is looking at how certain blood factors affect recovery after a less invasive heart procedure called TAVR, which is used to treat severe aortic stenosis, to help doctors find better ways to prevent complications and improve patient outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $179,604 |
| NIH project number | 5K23HL151872-05 |
| Project ID | NIH-10864053 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with severe aortic stenosis who are undergoing transcatheter aortic valve replacement.
✕Less likely to help
Patients who are not undergoing TAVR or those with mild aortic stenosis may not benefit from this research.
What this research studies
This research focuses on patients undergoing transcatheter aortic valve replacement (TAVR), a less invasive procedure for treating severe aortic stenosis. The study aims to understand how platelets and hemostatic factors contribute to inflammation and complications following the procedure. By analyzing blood samples and patient outcomes, the research seeks to identify patterns that could predict complications like bleeding and thromboembolic events. The ultimate goal is to improve patient outcomes and survival rates after TAVR by optimizing treatment strategies based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to improved management of complications following TAVR, enhancing patient survival and quality of life.
How similar studies have gone: Previous research has shown that understanding the thromboinflammatory response can significantly impact patient outcomes in similar cardiac procedures.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Lynch, Donald Ray — University of Cincinnati
- Study coordinator: Lynch, Donald Ray
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.