Investigating how platelets and blood factors affect inflammation after heart valve replacement
Platelets and Hemostatic Factors as Facilitators of the Inflammatory Response Following Transcatheter Aortic Valve Replacement
This study is looking at how certain blood factors affect recovery after a less invasive heart procedure called TAVR, which is used to treat severe aortic stenosis, to help doctors find better ways to prevent complications and improve patient outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10864053 on NIH RePORTER |
What this research studies
This research focuses on patients undergoing transcatheter aortic valve replacement (TAVR), a less invasive procedure for treating severe aortic stenosis. The study aims to understand how platelets and hemostatic factors contribute to inflammation and complications following the procedure. By analyzing blood samples and patient outcomes, the research seeks to identify patterns that could predict complications like bleeding and thromboembolic events. The ultimate goal is to improve patient outcomes and survival rates after TAVR by optimizing treatment strategies based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with severe aortic stenosis who are undergoing transcatheter aortic valve replacement.
Not a fit: Patients who are not undergoing TAVR or those with mild aortic stenosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management of complications following TAVR, enhancing patient survival and quality of life.
How similar studies have performed: Previous research has shown that understanding the thromboinflammatory response can significantly impact patient outcomes in similar cardiac procedures.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Lynch, Donald Ray — University of Cincinnati
- Study coordinator: Lynch, Donald Ray
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.