Velocity-based resistance training to reduce inflammation in older adults
Dose-Response Effects of Velocity-Based Resistance Training on Anti-Inflammatory Responses in Older Adults
NA · National Taipei University · NCT07566832
This program will test whether different amounts of velocity-based resistance training can lower inflammation in adults aged 60–75 who do not regularly do resistance exercise.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 60 Years to 75 Years |
| Sex | All |
| Sponsor | National Taipei University (other) |
| Locations | 1 site (Taipei) |
| Trial ID | NCT07566832 on ClinicalTrials.gov |
What this trial studies
This randomized intervention assigns older adults to low-, medium-, or high-volume velocity-based resistance training or a non-exercise control. Training groups complete a supervised 4-week resistance program emphasizing movement velocity followed by a 4-week detraining phase. Researchers will measure immune and anti-inflammatory markers before training, after training, and after detraining to determine volume-specific effects. The protocol excludes participants with obesity, chronic diseases, regular anti-inflammatory medication use, smoking, or recent musculoskeletal injury to better isolate exercise effects.
Who should consider this trial
Good fit: Ideal candidates are otherwise healthy adults aged 60–75 who have not engaged in regular resistance training (≥2 sessions/week) in the past year and can safely perform supervised resistance movements.
Not a fit: People with obesity (BMI >30 kg/m²), diabetes, hypertension, cancer, significant heart/kidney/liver disease, regular anti-inflammatory medication use, smoking or alcohol abuse, or inability to perform the exercises safely are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the results could identify optimal training volumes to lower inflammation and help clinicians prescribe resistance exercise to support healthier aging.
How similar studies have performed: Previous studies have shown resistance training can reduce inflammatory markers in older adults, but velocity-based and volume-specific effects are less well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 60-75 years or older * No regular resistance training habit (defined as ≥2 sessions per week) in the past year * No musculoskeletal injuries within the past six months Exclusion Criteria: * Obesity (BMI \> 30 kg/m²), diabetes, hypertension, cancer, heart, kidney, or liver disease, or any other condition that may influence study outcomes. * Regular use of anti-inflammatory medications (e.g., NSAIDs). * Smoking or alcohol abuse * Inability to safely perform the prescribed resistance exercise movements * Unable to fully comprehend the study information and instructions.
Where this trial is running
Taipei
- National Taiwan Normal University — Taipei, Taiwan (RECRUITING)
Study contacts
- Principal investigator: Shun-Hsi Tsai, Ph.D. — National Taipei University
- Study coordinator: Shun-Hsi Tsai, Ph.D.
- Email: shunhsi@mail.ntpu.edu.tw
- Phone: +88686741111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aging, Inflammatory Response