Understanding how DNMT3A mutations affect inflammation in older adults
Official title: Altered inflammatory response associated with acquired DNMT3A mutations
Funded at University of California-Irvine · NIH-11077823 · Data updated 2026-11-12
This study is looking at how certain changes in blood cells, which are more common in people over 60, might increase inflammation and health risks like cancer and heart disease, with the goal of finding new ways to help manage these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | May 1, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $519,617 |
| NIH project number | 5R01HL153974-05 |
| Project ID | NIH-11077823 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those aged 60 and above, who may carry DNMT3A mutations.
✕Less likely to help
Patients who are younger than 60 or do not have DNMT3A mutations may not benefit from this research.
What this research studies
This research investigates the role of DNMT3A mutations in blood cells and their link to increased inflammation and health risks in older adults. It focuses on how these mutations, which are common in individuals aged 60 and above, may lead to a heightened risk of cancers and heart disease. By studying human macrophages derived from pluripotent stem cells, the research aims to uncover the molecular mechanisms behind the altered inflammatory responses associated with these mutations. This could provide insights into potential therapeutic targets for managing inflammation and related diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating hematologic cancers and cardiovascular diseases in older adults.
How similar studies have gone: Previous studies have shown promising results in understanding the role of DNMT3A mutations in inflammation, but this specific approach using human myeloid cells is relatively novel.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Byun, Minji — University of California-Irvine
- Study coordinator: Byun, Minji
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.