Improving insulin infusion devices to reduce inflammation and extend use.
Official title: Infusion device optimization by addressing root causes of the inflammatory response
Funded at Wayne State University · NIH-11049078 · Data updated 2026-11-12
This study is looking at ways to make insulin delivery devices better for people with diabetes by figuring out how to reduce skin irritation caused by certain preservatives in insulin, so you can wear your infusion sets longer and manage your diabetes more easily.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | April 20, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $510,643 |
| NIH project number | 5R01DK129681-04 |
| Project ID | NIH-11049078 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who use insulin infusion pumps and experience issues with infusion site inflammation.
✕Less likely to help
Patients who do not use insulin infusion devices or those with diabetes managed solely through oral medications may not benefit from this research.
What this research studies
This research focuses on enhancing insulin infusion devices used by diabetes patients by addressing the root causes of inflammation that limit their effectiveness. The team is investigating how certain preservatives in insulin can cause skin irritation and inflammation, which in turn shortens the lifespan of infusion sets. By removing these harmful preservatives before infusion, the researchers aim to reduce inflammation and improve the overall performance of insulin delivery systems. This could lead to longer wear times for infusion sets, providing patients with more reliable and effective diabetes management.
Why it matters
Potential benefit: If successful, this research could lead to insulin infusion devices that can be worn longer without causing skin issues, improving diabetes management for patients.
How similar studies have gone: Previous research has shown promise in addressing similar issues with insulin delivery systems, indicating that this approach could lead to meaningful advancements.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Klueh, Ulrike — Wayne State University
- Study coordinator: Klueh, Ulrike
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.