How estrogen affects immune response and lung inflammation in certain lung diseases
Official title: Estrogen-mediated effects on neutrophil function and airway inflammatory response
Funded at Ut Southwestern Medical Center · NIH-10991292 · Data updated 2026-11-12
This study is looking at how estrogen affects immune cells and lung inflammation in women with Cystic Fibrosis and nonCF bronchiectasis, to understand why they often have worse health than men, especially when estrogen levels are high, and to find ways to help improve their lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 17, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $574,000 |
| NIH project number | 1R01HL175722-01 |
| Project ID | NIH-10991292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are females diagnosed with Cystic Fibrosis or nonCF bronchiectasis, particularly those experiencing frequent lung infections or exacerbations.
✕Less likely to help
Patients who are male or those without a diagnosis of Cystic Fibrosis or nonCF bronchiectasis may not benefit from this research.
What this research studies
This research investigates the role of estrogen in influencing neutrophil function and airway inflammation in patients with Cystic Fibrosis (CF) and nonCF bronchiectasis (NCFB). The study aims to understand why females with these conditions experience worse health outcomes compared to males, particularly during times of high estrogen levels. By examining the relationship between estrogen and immune responses, the research seeks to identify potential therapeutic strategies that could improve lung health. Patients may be involved in assessments of their lung function and inflammatory markers in relation to hormonal changes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for lung diseases in females, potentially enhancing their quality of life and health outcomes.
How similar studies have gone: Previous research has indicated that hormonal factors can influence immune responses, suggesting that this approach may yield valuable insights into treatment strategies.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Jain, Raksha — Ut Southwestern Medical Center
- Study coordinator: Jain, Raksha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.