How acetate affects blood cell development and inflammation
Official title: Acetate as a Mediator of Hematopoietic Stem Cell Inflammatory Response and Clonal Hematopoiesis
Funded at Baylor College of Medicine · NIH-10996111 · Data updated 2026-11-12
This study is looking at how a substance called acetate, which increases when we have inflammation, affects the behavior of blood-forming cells, and it aims to help people understand how diet and inflammation might influence blood health and related issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HL164097-03 |
| Project ID | NIH-10996111 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may have conditions related to inflammation or clonal hematopoiesis.
✕Less likely to help
Patients with non-inflammatory blood disorders or those under 21 years old may not receive benefits from this research.
What this research studies
This research investigates the role of acetate, a metabolic signal that increases during inflammation, in the behavior of hematopoietic stem and progenitor cells (HSPCs) which are crucial for blood cell formation. The study aims to understand how changes in acetate levels influence these cells' responses to inflammatory signals, particularly in the context of clonal hematopoiesis, where certain mutant blood cell clones become more prevalent. By examining the effects of acetate on gene expression and inflammatory responses, the research seeks to uncover potential dietary influences on blood health and disease. Patients may benefit from insights into how inflammation and diet interact to affect blood cell development and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations or treatments that help manage blood-related diseases linked to inflammation.
How similar studies have gone: While the role of acetate in metabolism is known, this specific investigation into its effects on hematopoietic stem cells during inflammation is relatively novel.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Tiessen, Jonathan — Baylor College of Medicine
- Study coordinator: Tiessen, Jonathan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.