Monitoring severe COVID-19 infections in children in Israel and England

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to conduct prospective surveillance of severe morbidity related to COVID-19 infection in children presenting to Pediatric Emergency Departments in Israel and the UK. It will involve a multicenter approach across multiple hospitals, focusing on children aged 16 years or younger who have a confirmed acute COVID-19 infection. The confirmation will be based on polymerase chain reaction testing of nasopharyngeal swabs. The study will also include patients diagnosed with multisystem inflammatory syndrome in children (MIS-C).

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. SACI

   Patients aged 16 years or younger with a positive COVID-19 PCR nasopharyngeal swab testing or bronchoalveolar sample who meet the definition of SACI:
   * Receive oxygen via low-flow nasal cannula or oxygen mask, high-flow nasal cannula, bilevel or continuous positive airway pressure machine, mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) Or
   * Admitted to ICU
2. MIS-C Patients aged 16 years or younger diagnosed with MIS-C

Where it's running

• Haemek Medical Center
  Afula, Israel Recruiting
• Soroka Medical Center
  Beersheba, Israel Recruiting
• Hadassah Medical Center
  Jerusalem, Israel Recruiting
• Shaare Zedek Medical Center
  Jerusalem, Israel Recruiting
• Meir Medical Center
  Kfar Saba, Israel Recruiting
• Sheba Medical Center
  Tel HaShomer, Israel Recruiting

Study contacts

• Study coordinator: Itai Shavit, MD
• Email: shavit1@hadassah.org.il
• Phone: 00 972 50 2063239

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.