Understanding how immune cells contribute to lung injury
hHv1 channels in neutrophils and the innate immune inflammatory response
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11171714
This research explores how certain immune cells called neutrophils cause lung damage in conditions like acute lung injury and ARDS, aiming to find new ways to protect the lungs.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11171714 on ClinicalTrials.gov |
What this research studies
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe conditions where fluid builds up in the lungs, often leading to high mortality. Current treatments that target later stages of inflammation haven't been very successful. This project focuses on a specific protein, hHv1, found in immune cells called neutrophils, which are known to release harmful substances that damage the lungs. By developing a unique blocker for hHv1, researchers hope to stop this inflammatory process early on. This approach could potentially prevent or reduce lung damage in patients with these serious conditions.
Who could benefit from this research
Good fit: Future patients suffering from or at risk of acute lung injury or acute respiratory distress syndrome could potentially benefit from this research.
Not a fit: Patients without acute lung injury or ARDS, or those whose lung damage is caused by mechanisms unrelated to hHv1, may not directly benefit from this specific approach.
Why it matters
Potential benefit: If successful, this work could lead to new drug therapies that target the hHv1 protein to prevent or reduce severe lung damage in patients with acute lung injury and ARDS.
How similar studies have performed: This project builds on recent advances in creating a specific blocker for hHv1, which has shown promise in suppressing inflammation in human cells and lung damage in animal models.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOLDSTEIN, STEVE A N — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: GOLDSTEIN, STEVE A N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury, Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome