Investigating how platelets and blood factors affect inflammation after heart valve replacement
Platelets and Hemostatic Factors as Facilitators of the Inflammatory Response Following Transcatheter Aortic Valve Replacement
This study is looking at how blood platelets and other factors affect recovery after a heart procedure called TAVR, which helps people with a narrowed aortic valve, and it aims to find ways to make the procedure safer and more effective for patients who can't have regular surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11136778 on NIH RePORTER |
What this research studies
This research focuses on patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis, a condition that narrows the heart's aortic valve. The study aims to understand how platelets and hemostatic factors contribute to inflammation and complications following the procedure. By analyzing blood samples and patient outcomes, researchers hope to identify patterns that could improve recovery and survival rates. The ultimate goal is to enhance the safety and effectiveness of TAVR, particularly for those who are not candidates for traditional surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with severe aortic stenosis who are undergoing transcatheter aortic valve replacement.
Not a fit: Patients who are not undergoing TAVR or those with mild aortic stenosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols that enhance recovery and survival rates for patients undergoing TAVR.
How similar studies have performed: Previous research has shown promising results in understanding thromboinflammatory responses in similar patient populations, indicating potential for success in this approach.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Lynch, Donald Ray — University of Cincinnati
- Study coordinator: Lynch, Donald Ray
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.