Investigating how platelets and blood factors affect inflammation after heart valve replacement
Official title: Platelets and Hemostatic Factors as Facilitators of the Inflammatory Response Following Transcatheter Aortic Valve Replacement
Funded at University of Cincinnati · NIH-11136778 · Data updated 2026-11-12
This study is looking at how blood platelets and other factors affect recovery after a heart procedure called TAVR, which helps people with a narrowed aortic valve, and it aims to find ways to make the procedure safer and more effective for patients who can't have regular surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $75,600 |
| NIH project number | 3K23HL151872-05S1 |
| Project ID | NIH-11136778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with severe aortic stenosis who are undergoing transcatheter aortic valve replacement.
✕Less likely to help
Patients who are not undergoing TAVR or those with mild aortic stenosis may not benefit from this research.
What this research studies
This research focuses on patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis, a condition that narrows the heart's aortic valve. The study aims to understand how platelets and hemostatic factors contribute to inflammation and complications following the procedure. By analyzing blood samples and patient outcomes, researchers hope to identify patterns that could improve recovery and survival rates. The ultimate goal is to enhance the safety and effectiveness of TAVR, particularly for those who are not candidates for traditional surgery.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols that enhance recovery and survival rates for patients undergoing TAVR.
How similar studies have gone: Previous research has shown promising results in understanding thromboinflammatory responses in similar patient populations, indicating potential for success in this approach.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Lynch, Donald Ray — University of Cincinnati
- Study coordinator: Lynch, Donald Ray
Related research
Other NIH-funded projects on the same topics.
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Investigating how platelets and blood factors affect inflammation after heart valve replacement
This study is looking at how certain blood factors affect recovery after a less invasive heart procedure called TAVR, which is used to treat severe aortic stenosis, to help doctors find better ways to prevent complications and improve patient outcomes.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.