Effects of hop compounds on the immune system in overweight individuals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of Xanthohumol and Iso-alpha Acids, derived from hops, on the immune response in overweight participants who may have incipient metabolic diseases. Participants will consume a study drink containing these compounds along with a light breakfast, followed by multiple blood samples taken over several hours to assess various clinical parameters and inflammatory markers. The goal is to determine the protective effects of these compounds on isolated blood cells and how they differ from those in normal-weight individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* BMI 25 - 29,9 kg/m²

as well as one or more of the following incipient metabolic diseases:

* pre-diabetes (fasting blood glucose 100-125 mg/dL),
* fatty liver (grade 1-3),
* high-normal blood pressure to mild hypertension (grade 1, systolic 140-159 mmHg)

Exclusion Criteria:

* History of diseases that could falsify the study results
* inflammatory bowel diseases
* malignant diseases of the gastrointestinal tract
* food allergies
* malabsorption
* kidney or liver disease (except simple fatty liver)
* symptomatic heart failure
* Taking medication to treat these diseases
* Consumption of special diets (e.g. vegan, gluten-free)
* Pregnancy

Where it's running

• University of Vienna
  Vienna, Austria Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.