Understanding the immune response to COVID-19
Official title: Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2
Funded at Cedars-Sinai Medical Center · NIH-11171035 · Data updated 2026-11-12
This study is looking at how different people's bodies react to the COVID-19 virus, especially how their immune systems respond, and it's for anyone with COVID-19 or healthcare workers, as it aims to learn more about how the illness progresses and what helps people recover.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 30, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $989,284 |
| NIH project number | 3U54CA260591-02S4 |
| Project ID | NIH-11171035 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been diagnosed with COVID-19 or healthcare workers involved in treating COVID-19 patients.
✕Less likely to help
Patients who have not been exposed to SARS-CoV-2 or those without any symptoms related to COVID-19 may not benefit from this research.
What this research studies
This research investigates how different individuals respond to the SARS-CoV-2 virus, focusing on the immune and inflammatory responses that can affect the severity of COVID-19. By studying patients with confirmed or suspected COVID-19 and healthcare workers, the research aims to gather extensive data on illness progression, recovery, and potential immunity. The approach includes longitudinal data collection and analysis to identify risk factors and outcomes associated with COVID-19. Patients will be monitored over time to better understand their immune responses and the factors that influence their health.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of COVID-19, helping to identify at-risk populations and inform better treatment strategies.
How similar studies have gone: Other research has shown success in understanding immune responses to viral infections, making this approach promising but still requiring further exploration specific to COVID-19.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Figueiredo, Jane C. — Cedars-Sinai Medical Center
- Study coordinator: Figueiredo, Jane C.
Related research
Other NIH-funded projects on the same topics.
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Understanding the immune response to SARS-CoV-2 in diverse populations
This study is looking at how different groups of people, including COVID-19 patients and healthcare workers, react to the virus to better understand how the illness progresses and how the body fights it, all to help improve care and recovery for everyone affected by COVID-19.
-
Understanding how different people respond to COVID-19 vaccines
This study is looking at how the immune system reacts to COVID-19 in people with weakened immune systems, and it aims to use this information to improve vaccine and booster recommendations to keep everyone healthier.
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Understanding how different people respond to COVID-19
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How COVID-19 infection and genes may influence memory and dementia risk
This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.
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SSRI use during pregnancy: effects on placental blood flow and inflammation
This grant studies how antidepressants (SSRIs) used during pregnancy might affect the placenta and inflammation, and whether a 5-HT2 receptor blocker could mitigate any negative effects.
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Understanding flu and COVID-19 vaccine responses in people and in the lab
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.