Understanding how skin inflammation is controlled to help conditions like atopic dermatitis
Official title: Regulators of the Skin Inflammatory Response
Funded at University of California, San Diego · NIH-11421881 · Data updated 2026-11-12
A study at UC San Diego investigates how skin cells regulate inflammation to prevent prolonged skin redness and injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $559,827 |
| NIH project number | 1R01AR087994-01 |
| Project ID | NIH-11421881 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with inflammatory skin conditions like psoriasis or atopic dermatitis who may benefit from improved control of skin inflammation.
✕Less likely to help
People without inflammatory skin conditions or those not affected by epidermal inflammatory dysregulation may not benefit.
What this research studies
Researchers will examine the molecular partners that keep skin inflammation in check, focusing on keratinocytes in the epidermis and a silencing complex involving ZNF750. The work will explore how this complex dampens key inflammatory signals when skin is challenged by bacteria or irritation. By mapping which inflammatory genes are directly controlled, the project aims to reveal why some inflammatory responses become excessive and chronic. The findings could point to new ways to prevent or treat inflammatory skin diseases in patients.
Why it matters
Potential benefit: If successful, this research could lead to new targets for therapies that reduce chronic skin inflammation.
How similar studies have gone: Previous work suggests specific skin regulators can dampen inflammation, but the exact role of ZNF750 and its partners is still being clarified.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Sen, George L — University of California, San Diego
- Study coordinator: Sen, George L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.