Understanding how different people respond to COVID-19 vaccines
Official title: Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2
Funded at Cedars-Sinai Medical Center · NIH-10706736 · Data updated 2026-11-12
This study is looking at how the immune system reacts to COVID-19 in people with weakened immune systems, and it aims to use this information to improve vaccine and booster recommendations to keep everyone healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 30, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $195,001 |
| NIH project number | 3U54CA260591-02S2 |
| Project ID | NIH-10706736 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include immunocompromised individuals who may have varied responses to COVID-19 vaccines.
✕Less likely to help
Patients who are not immunocompromised or those who do not have access to the participating healthcare sites may not benefit from this research.
What this research studies
This research aims to gather and analyze data on the immune and inflammatory responses to SARS-CoV-2, particularly focusing on immunocompromised individuals. By pooling information from various healthcare sites across North America, the study will create a comprehensive dataset that reflects diverse populations. The goal is to inform public health guidelines regarding COVID-19 vaccines and boosters, ultimately helping to reduce infections and severe illness. Patients' electronic medical records and data from prospective cohorts will be harmonized for thorough analysis.
Why it matters
Potential benefit: If successful, this research could lead to improved COVID-19 vaccination strategies that better protect vulnerable populations.
How similar studies have gone: Other research has successfully utilized similar cohort pooling strategies to enhance understanding of vaccine responses in diverse populations.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Figueiredo, Jane C. — Cedars-Sinai Medical Center
- Study coordinator: Figueiredo, Jane C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.