Investigating how certain immune cells respond to lung damage from ozone exposure
Monocyte-derived alveolar macrophage drives inflammatory response to lung ozone exposure
This study is looking at how certain immune cells in the lungs react to damage from ozone, especially in people who have had previous lung infections, to help find better ways to treat breathing problems caused by air pollution.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11121823 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific immune cells, known as alveolar macrophages, in the body's response to lung injury caused by ozone exposure. It aims to uncover how prior lung damage, particularly from viral infections, affects the immune response to ozone, which is a significant public health concern. The study will involve examining the behavior of these immune cells in both mice and humans to identify mechanisms that could lead to better treatments for respiratory conditions exacerbated by ozone. By analyzing how these immune cells function and interact during lung injury, the research seeks to provide insights into preventing and managing respiratory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with pre-existing respiratory conditions, particularly those who have experienced lung injuries from viral infections.
Not a fit: Patients without any history of respiratory issues or lung injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for protecting patients with respiratory conditions from the harmful effects of ozone exposure.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to environmental exposures, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Tighe, Robert Matthew — Duke University
- Study coordinator: Tighe, Robert Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.