Using tranexamic acid to reduce inflammation in traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This double-blind phase 3 trial investigates the effects of tranexamic acid (TXA) on inflammation in patients with traumatic brain injury (TBI). Participants will be randomly assigned to receive either TXA or a saline placebo after initial resuscitation in the emergency room. The study will monitor various inflammatory markers and clinical outcomes, including the Glasgow Coma Scale and hemodynamic stability, over a period of 48 hours. The goal is to determine if TXA can effectively modulate the inflammatory response associated with TBI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Isolated traumatic brain injury patients (mild or moderate cases)
* GCS \> 8
* non penetrating TBI in 8 hours onset
* Age ≥ 18 years

Exclusion Criteria:

* Patient in cardiac arrest
* Patients with coagulopathies
* All diabetic patients
* Renal failure patients
* pregnancy
* Patient refusal to participate

Where it's running

• Assiut university hospital
  Asyut, Assuit, Egypt Recruiting

Study contacts

• Study coordinator: Omar Soliman
• Email: omar@aun.edu.eg
• Phone: 01101266040

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.