Condition

Inflammatory Bowel Disease clinical trials and research

• 26Clinical trials
• 110NIH research projects
• 12Countries

Newest Inflammatory Bowel Disease clinical trials

All recruiting trials (26)

• Fecal Transplants from Dai vs Han Donors for Ulcerative Colitis

  This study tests whether fecal microbiota transplantation from healthy Dai donors improves symptoms in adults with ulcerative colitis more than transplantation from healthy Han donors.

  Recruiting Phase 2 First Affiliated Hospital of Kunming Medical University · Kunming, Yunnan · NCT07814456

• Longitudinal Immunophenotyping of People with Inflammatory Bowel Disease

  This study will follow adults with Crohn's disease or ulcerative colitis (and some healthy relatives) over three years to see how their immune cells change over time and how genetics and diet relate to their disease.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07619547

• Breast milk mirikizumab levels in lactating people using mirikizumab for IBS/IBD

  This study tests how much mirikizumab passes into breast milk for people who are breastfeeding while on mirikizumab for an approved condition.

  Recruiting at 2 sites Phase 4 Eli Lilly and Company · Glenview, Illinois and 19 other locations · NCT07612267

• Real-world use of guselkumab in Crohn’s disease and ulcerative colitis

  This study tests how long guselkumab stays in the bodies of adults with moderate-to-severe Crohn’s disease or ulcerative colitis treated in real-world clinical settings.

  Recruiting Janssen-Cilag A.G., Switzerland · Bern · NCT07532213

• Gut microbiome and metabolites in people with IBD and depression

  This project will test whether gut microbes and metabolites differ in adults with IBD who have depression compared with those without depression and with healthy adults.

  Recruiting Qianfoshan Hospital · Jinan, Shandong · NCT07252427

• Real-world use of guselkumab for adults with moderate-to-severe ulcerative colitis and Crohn's disease in the UK

  This project will see how well guselkumab works for adults with moderate-to-severe ulcerative colitis or Crohn's disease who are starting the treatment in routine UK care.

  Recruiting Janssen-Cilag Ltd. · Harrow · NCT07242248

• Measurement-based care to improve quality of life and disease management in Veterans with inflammatory bowel disease

  The trial will test whether regularly collecting and acting on Veterans' symptom reports helps people with inflammatory bowel disease feel better and have fewer flares over 12 months.

  Recruiting VA Office of Research and Development · Decatur, Georgia and 3 other locations · NCT07210580

• Morning light therapy for ulcerative colitis with poor sleep

  This pilot will test whether one hour of morning light therapy can improve sleep and lower inflammation in adults with ulcerative colitis who have poor sleep and signs of active inflammation.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07207200

• Guselkumab treatment for Crohn's disease and ulcerative colitis in Germany

  This project will try to see how well guselkumab works and how it affects symptoms, quality of life, and daily activities for adults with Crohn's disease or ulcerative colitis receiving routine care in Germany.

  Recruiting Janssen-Cilag G.m.b.H · Berlin · NCT07102368

• Evaluating Upadacitinib for Inflammatory Bowel Disease

  This study is testing how well the oral medication Upadacitinib works for people in China with Inflammatory Bowel Disease who haven't responded to other treatments.

  Recruiting at 6 sites Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong and 5 other locations · NCT06780683

• Evaluating COVID-19 and influenza vaccine schedules for immunocompromised individuals

  This study is testing different ways to give COVID-19 and flu vaccines to people with weakened immune systems to see which method works best for their protection.

  Recruiting at 2 sites Phase 2 McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec and 2 other locations · NCT06599658

• Evaluating SPH7854 Granules in Healthy Individuals

  This study is testing the safety of SPH7854 granules in healthy people to see if there are any side effects compared to a placebo.

  Recruiting Early Phase 1 Shanghai Pharmaceuticals Holding Co., Ltd · Chengdu · NCT06483373

• Exploring the impact of microplastics on pregnant women with Crohn's disease

  This study is trying to see how microplastics and toxins in the environment affect gut health in pregnant women with Crohn's disease and their babies.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT06001450

• Investigating the Mediterranean Diet's Effects on Inflammatory Bowel Disease

  This study is trying to see if switching to a Mediterranean diet can help people with inflammatory bowel disease feel better and improve their health.

  Recruiting University of California, San Diego · San Diego, California · NCT05973500

• Using bright light therapy to improve intestinal health in Crohn's disease

  This study is testing if bright light therapy can help improve gut health and reduce inflammation in people with Crohn's disease and ulcerative colitis.

  Recruiting at 2 sites Rush University Medical Center · Chicago, Illinois and 1 other locations · NCT05579392

• Understanding Inflammatory Bowel Disease in Children at Assiut University Hospital

  This study looks at children with inflammatory bowel disease to see what factors might affect their condition and how it can be better managed.

  Recruiting Assiut University · Asyut · NCT05002166

• Educational tool for melanoma patients with autoimmune diseases

  This study is testing a new educational tool to help melanoma patients with autoimmune diseases understand their treatment options better and see how easy it is for them to use.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04751396

• Evaluating bone health in adolescents with Crohn disease

  This study is trying to see how Crohn disease affects bone health in teenagers by comparing their bone density and marrow fat to those of healthy teens.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04508088

• High dose vitamin D for young patients with inflammatory bowel disease on biologic therapy

  This study is testing if giving high doses of vitamin D to young people with inflammatory bowel disease who are on biologic treatments can improve their bone health and reduce inflammation.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04331639

• Assessing health and exercise responses in children with chronic diseases

  This study is testing how chronic diseases and their treatments affect physical fitness in children and teens to find ways to improve their health and quality of life through exercise.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT03913962

• Using nivolumab to treat patients with autoimmune disorders and advanced cancer

  This study is testing if nivolumab can safely help people with autoimmune disorders who also have advanced cancer by looking at how well it works and what side effects it might cause.

  Recruiting at 40 sites Phase 1 National Cancer Institute (NCI) · Birmingham, Alabama and 51 other locations · NCT03816345

• Effects of a fasting mimicking diet on ulcerative colitis

  This study is testing whether a fasting mimicking diet can help reduce inflammation and improve quality of life for people with mild to moderate ulcerative colitis.

  Recruiting Stanford University · Palo Alto, California · NCT03615690

• Characterizing genetic and phenotypic traits of early onset enteropathies

  This study is trying to understand the genetic and physical traits of young children with early onset gut issues to see how their bodies handle gut health despite having many microbes.

  Recruiting at 11 sites Imagine Institute · Bordeaux and 11 other locations · NCT02614911

• Investigating serotonin signaling in patients with inflammatory bowel disease

  This study looks at how changes in serotonin signaling might affect people with inflammatory bowel disease, like Crohn's disease and ulcerative colitis, to help find new ways to manage their symptoms.

  Recruiting McMaster University · Hamilton, Ontario · NCT01650311

• Study on pregnancy outcomes in women with inflammatory bowel disease

  This study looks at how inflammatory bowel disease and the medications used to treat it affect pregnancy and baby health in women over many years.

  Recruiting at 2 sites University of California, San Francisco · San Francisco, California and 1 other locations · NCT00904878

• Investigating immune regulation in inflammatory bowel diseases

  This study looks at how the immune system works in people with Crohn's disease and ulcerative colitis to see if it can help us understand their inflammation better and improve future treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001184

NIH-funded research (newest 40 of 110)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Mitochondrial Talks: How Energy Networks Shape Inflammatory Bowel Disease

  Aimed at people with inflammatory bowel disease (IBD), this project explores how tiny cell powerhouses in the gut may go out of balance and contribute to IBD, with the goal of restoring energy and reducing disease symptoms.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11421488

• Mn in inflammatory bowel disease: how manganese and genes may shape gut inflammation

  This grant studies how the mineral manganese and a specific gene variant may influence inflammatory bowel disease in people of different ages.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11420332

• AI-Enhanced Virtual Reality CBT to Reduce Anxiety for IBD Patients

  A home-based VR and AI-powered cognitive behavioral therapy program is being tested to help people with inflammatory bowel disease feel less anxious and improve their quality of life.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11415875

• Gasdermin-based epithelial function in inflammatory bowel disease

  A funding opportunity that explores how gasdermin proteins affect the lining of the gut and may influence inflammatory bowel disease.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11408704

• Intestinal chondroitin sulfate glycosaminoglycans and their role in inflammatory bowel disease

  A clinician-scientist mentoring program aims to advance understanding of how intestinal sugar molecules called chondroitin sulfate glycosaminoglycans influence inflammatory bowel disease and patient care.

  NIH research University of Washington · Seattle, United States · NIH-11406345

• Improving IBD outcomes through community awareness, referrals, and education

  A U01 grant will support programs to raise awareness, improve referrals, and educate patients and clinicians about inflammatory bowel disease to improve diagnosis and care.

  NIH research Crohn's and Colitis Fdn of America, INC. · New York, United States · NIH-11403048

• Engineered gut-targeted regulatory T cells for inflammatory bowel disease

  A new allogeneic, gut-focused cell therapy using engineered regulatory T cells to help people with inflammatory bowel disease feel better and stay in remission.

  NIH research Gentibio, INC. · Cambridge, United States · NIH-11394173

• Can random biopsies improve colon cancer screening in inflammatory bowel disease

  Doctors are testing whether taking random tissue samples during colonoscopy helps find precancerous changes in people with long-standing inflammatory bowel disease.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11392279

• New TREM-1 therapy for inflammatory bowel disease

  A new peptide-based therapy targeting the inflammatory TREM-1 pathway could help people with inflammatory bowel disease who don’t respond well to current treatments.

  NIH research Signablok, INC. · Worcester, United States · NIH-11387185

• Improving IBD outcomes and reducing disparities through everyday care, data, and education

  A multi-site program tests how social factors affect inflammatory bowel disease and whether new management and education can help people in diverse backgrounds feel better and stay healthier.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11383272

• Understanding what causes inflammatory bowel disease in diverse populations

  A study to map genetic variants linked to inflammatory bowel disease (IBD) and see how they work in people from different ancestries.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11380697

• Understanding how genetic genes contribute to inflammatory bowel disease in worms and human mini-intestines

  Researchers are testing how specific genes linked to inflammatory bowel disease affect gut biology using tiny worms and human-like mini-intestines to uncover mechanisms and potential new targets.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11378436

• IBD risk picture: personal risk and progression in diverse patients

  A broad study at Emory will look at how genetics, epigenetics, gut bacteria, and lifestyle factors like diet and alcohol influence how inflammatory bowel disease may get worse in people, especially in African American communities.

  NIH research Emory University · Atlanta, United States · NIH-11378027

• Targeting a receptor to stop damaging T cell movement in IBD

  A small grant explores a new way to treat inflammatory bowel disease by blocking a receptor that guides inflammatory T cells to the gut.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11374661

• Microplastics, gut inflammation, and mood in digestive disease (animal study)

  This project looks at how tiny plastic particles might affect mood-related behavior in an animal model of inflammatory bowel disease.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11374032

• Genomic and Immune Clues to Inflammatory Bowel Disease and Its Subtypes

  Researchers are studying how genetic and immune factors contribute to inflammatory bowel disease and its two main forms, Crohn’s disease and ulcerative colitis, using patient data and biological samples.

  NIH research Sinai Health System · Toronto, Canada · NIH-11372305

• Impaired RNA editing and inflammation in inflammatory bowel disease

  A study to understand how mistakes in RNA editing may drive inflammation in people with inflammatory bowel disease.

  NIH research Stanford University · Stanford, United States · NIH-11369118

• 2’-FL for maintaining remission in Crohn’s disease (pediatric and young adults)

  This study tests a food-derived sugar, 2’-fucosyllactose, as a safe daily supplement to help maintain remission in people with Crohn’s disease who are already on standard medicines.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11361690

• Functional roles of IBD genetics in how the body responds to microbes

  Scientists are studying how genetic differences in people with inflammatory bowel disease influence how their bodies react to microbes.

  NIH research Yale University · New Haven, United States · NIH-11360128

• RECLAIM: A one-day ACT program to help veterans with inflammatory bowel disease and mental health challenges

  A quick, practical ACT-based program delivered in GI clinics to help veterans with IBD manage symptoms and improve mood and quality of life.

  NIH research Michael E Debakey VA Medical Center · Houston, United States · NIH-11349443

• CD40 signaling blocker to treat inflammatory bowel disease

  A new small molecule aims to block CD40 signaling to reduce inflammation in people with inflammatory bowel disease, while avoiding blood clot risk and infections.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11345333

• Predicting pouchitis in inflammatory bowel disease through immune-epithelial profiling

  We’re studying people with inflammatory bowel disease who may need a pouch after surgery to see if we can predict pouchitis by looking at immune and tissue signals in the small intestine before the surgery.

  NIH research New York University School of Medicine · New York, United States · NIH-11343733

• Bidirectional brain-gut signaling in IBS-like symptoms in IBD

  Researchers will study how brain and gut signals interact to drive IBS-like symptoms in people with inflammatory bowel disease.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11343361

• Role of microbiota-specific T cells in inflammatory bowel disease

  A doctor-science team will study how the body's T cells that recognize gut microbes relate to inflammatory bowel disease in people and in a humanized mouse model.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11340316

• Gut health and PTSD in veterans with inflammatory bowel disease

  A study explores how the gut microbiome and chronic stress from military experiences may influence inflammatory bowel disease in veterans.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11333100

• Heart-rate biofeedback and coping skills to help teens with IBD feel less stressed

  This program teaches teens and young adults with Crohn's disease or ulcerative colitis breathing and heart‑rate biofeedback skills to lower stress, improve mood, and support gut health.

  NIH research Emory University · Atlanta, United States · NIH-11324588

• Processed foods, gut bacteria, and immune defenses in inflammatory bowel disease

  This project tests whether an ultra‑processed food–style diet changes gut bacteria and weakens immune defenses in people at risk for inflammatory bowel disease.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11322034

• How gut bacteria that scavenge zinc may affect inflammatory bowel disease

  Researchers are looking at whether bacteria in the gut that grab zinc make Crohn’s disease and ulcerative colitis worse.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11296935

• Gut bacteria stability in ulcerative colitis and Crohn’s disease

  Researchers are tracking gut bacteria over several years in people with ulcerative colitis and Crohn’s disease (and healthy volunteers) to see whether long-term bacterial stability links to flares and outcomes after fecal transplants.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11296873

• LSP1 gene in T cells and its role in inflammatory bowel disease

  This project looks at whether lower levels of the LSP1 gene in certain T cells push immune cells to drive worse inflammatory bowel disease in people with IBD.

  NIH research La Jolla Institute for Immunology · La Jolla, United States · NIH-11296838

• How fat tissue affects inflammatory bowel disease

  This study is looking at how the fat around your intestines might affect the severity of inflammatory bowel disease (IBD), like Crohn's disease and ulcerative colitis, especially in people who are obese, to help find better ways to manage or treat these conditions.

  NIH research Rutgers, the State Univ of N.j. · Piscataway, United States · NIH-11291136

• How neutrophil traps (NETs) and the PAD4 enzyme affect gut healing in IBD

  Researchers are looking at whether the enzyme PAD4 and the neutrophil traps it creates help protect the gut in people with Crohn’s disease or ulcerative colitis.

  NIH research University of Toledo Health Sci Campus · Toledo, United States · NIH-11290439

• Why lymphatic drainage changes in inflammatory bowel disease

  Researchers are studying how immune cells and damaged lymphatic vessels can block fluid flow in people with Crohn's disease.

  NIH research Washington University · Saint Louis, United States · NIH-11290395

• Gut microbes, fiber in your diet, and inflammatory bowel disease

  This grant explores how dietary fiber and gut bacteria influence inflammatory bowel disease and related inflammation in people and models.

  NIH research Georgia State University · Atlanta, United States · NIH-11288589

• PFAS exposure and gut inflammation risk in IBD

  A study to see if environmental chemicals called PFAS affect gut immune signals and raise the chance of developing inflammatory bowel disease.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11278633

• How a gut protein (P-glycoprotein) affects inflammatory bowel disease

  This work looks at whether problems with a gut protein called P‑glycoprotein contribute to ulcerative colitis and Crohn's disease and how that changes gut bacteria.

  NIH research Jesse Brown VA Medical Center · Chicago, United States · NIH-11264647

• Vitamin B5 might help inflammatory bowel disease

  A scientist is studying how Vitamin B5 found in food and gut bacteria could influence inflammatory bowel disease by supporting immune cells in the gut.

  NIH research Northwestern University · Chicago, United States · NIH-11263271

• Tiny cerium-oxide particles to make CT scans clearer and reduce IBD inflammation

  Researchers are developing sugar-coated cerium-oxide nanoparticles to help CT scans pinpoint inflamed bowel tissue and to lower inflammation in people with inflammatory bowel disease.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11251732

• How the CREM gene helps protect the gut in amebic colitis and inflammatory bowel disease

  This project looks at whether the CREM gene helps protect people from gut inflammation caused by amebiasis and inflammatory bowel disease.

  NIH research University of Virginia · Charlottesville, United States · NIH-11242003

• New PD-1 immune‑boosting treatment for inflammatory bowel disease

  This project develops a treatment that boosts PD‑1 immune signaling, alone and with low‑dose IL‑2, to help restore immune balance in people with inflammatory bowel disease.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11238448

Related topics

Quick answers

How many Inflammatory Bowel Disease clinical trials are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (14 trials), China (4 trials), Canada (4 trials), Germany (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Early Phase 1: 1, Phase 4: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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