Impaired RNA editing and inflammation in inflammatory bowel disease
Official title: Impaired cellular RNA editing as a cause of inflammation in inflammatory bowel disease
Funded at Stanford University · NIH-11369118 · Data updated 2026-11-12
A study to understand how mistakes in RNA editing may drive inflammation in people with inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $455,228 |
| NIH project number | 5R01DK140912-03 |
| Project ID | NIH-11369118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with Crohn’s disease or ulcerative colitis or individuals at risk with identifiable dsRNA editing pathway dysregulation.
✕Less likely to help
Individuals without IBD or without the specific biological editing abnormalities studied may not benefit.
What this research studies
This project explores how errors in the cellular RNA editing process, especially involving the ADAR1 protein, contribute to inflammation in Crohn’s disease and ulcerative colitis. Researchers will use animal models to link dsRNA sensing and immune activation to IBD risk loci identified in humans. The work aims to map how editing deficits trigger inflammatory signals and how this connects to genetic risk, with the goal of identifying targets to reduce harmful immune responses. The findings could point toward new ways to prevent or treat inflammation in IBD.
Why it matters
Potential benefit: If successful, the work could lead to novel approaches to calm intestinal inflammation in IBD patients.
How similar studies have gone: Previous work shows that RNA editing and dsRNA sensing pathways influence inflammation, supporting potential relevance to IBD, though precise human application remains investigational.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Li, Jin Billy — Stanford University
- Study coordinator: Li, Jin Billy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.