Genomic and Immune Clues to Inflammatory Bowel Disease and Its Subtypes
Official title: Genomic and Immunologic Characterization of Inflammatory Bowel Disease and its Phenotypes
Funded at Sinai Health System · NIH-11372305 · Data updated 2026-11-12
Researchers are studying how genetic and immune factors contribute to inflammatory bowel disease and its two main forms, Crohn’s disease and ulcerative colitis, using patient data and biological samples.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sinai Health System NIH-funded |
| Lab location | 1 site (Toronto, Canada) |
| Project start | September 30, 2002 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $392,842 |
| NIH project number | 5U01DK062423-25 |
| Project ID | NIH-11372305 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with inflammatory bowel disease (Crohn’s disease or ulcerative colitis) who are part of the established registry and have related biospecimens available.
✕Less likely to help
Patients not represented in the registry or without related biospecimens may not directly benefit from this research.
What this research studies
This project will use a large registry of well-characterized IBD patients and stored biospecimens to explore how genetic variants and immune responses drive disease. By combining genomic, cellular, and immune profiling, the team aims to connect specific genes to disease pathways and to differences between Crohn’s disease and ulcerative colitis. The work builds on years of collaboration across genetic research centers to illuminate IBD mechanisms and identify potential targets for therapy. The study leverages existing patient resources to push forward understanding of IBD at a deeper, systems level.
Why it matters
Potential benefit: If successful, the findings could lead to better prediction of disease course and new approaches to treatment tailored to a patient’s genetic and immune profile.
How similar studies have gone: Prior GWAS and consortium efforts have identified many risk variants, and this project seeks to translate those findings into a clearer pathophysiological understanding.
Where this research is happening
-
Sinai Health System
Toronto, Canada Active
Researchers
- Principal investigator: Silverberg, Mark S. — Sinai Health System
- Study coordinator: Silverberg, Mark S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.