PFAS exposure and gut inflammation risk in IBD
Official title: Per- and poly-fluoroalkyl substances (PFAS) exposure and glycosylation alterations preceding inflammatory bowel disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-11278633 · Data updated 2026-11-12
A study to see if environmental chemicals called PFAS affect gut immune signals and raise the chance of developing inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 17, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $698,943 |
| NIH project number | 1R01DK145743-01 |
| Project ID | NIH-11278633 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults and children who may be at risk for IBD or have related exposure histories, and individuals with blood samples showing PFAS exposure or altered glycosylation.
✕Less likely to help
People without PFAS exposure histories or without progression toward IBD are less likely to benefit directly.
What this research studies
This study looks at how PFAS chemicals in the environment might change the body's gut lining and blood sugar signals before IBD develops. It uses data from people and biological samples to explore links between PFAS mixtures, changes in serum glycosylation, and later IBD risk. Researchers plan to integrate epidemiology with lab work to understand possible mechanisms and identify early biomarkers. The goal is to better predict who may become at risk and why, so prevention or early interventions can be more effectively targeted.
Why it matters
Potential benefit: If successful, it could improve understanding of how environment affects IBD risk and help identify people who should be monitored more closely.
How similar studies have gone: Prior work suggests PFAS exposure and glycosylation changes are linked to IBD, but this study aims to examine multiple PFAS and longitudinal risk.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Agrawal, Manasi — Icahn School of Medicine at Mount Sinai
- Study coordinator: Agrawal, Manasi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.