Predicting pouchitis in inflammatory bowel disease through immune-epithelial profiling
Funded at New York University School of Medicine · NIH-11343733 · Data updated 2026-11-12
We’re studying people with inflammatory bowel disease who may need a pouch after surgery to see if we can predict pouchitis by looking at immune and tissue signals in the small intestine before the surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 14, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $845,994 |
| NIH project number | 1R01DK147073-01 |
| Project ID | NIH-11343733 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with inflammatory bowel disease (ulcerative colitis or colonic Crohn’s disease) who are candidates for restorative proctocolectomy with IPAA.
✕Less likely to help
Participants without pre-surgical ileal tissue samples or without subsequent pouchitis may have limited direct benefit.
What this research studies
This project looks at the immune and epithelial environment in the ileum before restorative proctocolectomy with IPAA in patients with ulcerative colitis or colonic Crohn’s disease. Using advanced single-cell sequencing, it aims to identify immune cell patterns, such as Th17 cells, and epithelial changes that precede pouchitis. The study will relate these pre-surgery tissue signals to later pouch inflammation and test whether stem-cell–derived tissue shows durable epigenetic changes linked to disease risk. Ultimately, findings could guide personalized risk prediction and prevention strategies for pouchitis after IPAA.
Why it matters
Potential benefit: If successful, patients could receive earlier risk stratification for pouchitis and tailored preventive approaches after IPAA surgery.
How similar studies have gone: Preliminary single-cell approaches have identified immune-epithelial signatures associated with pouchitis, supporting potential predictive value.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Axelrad, Jordan Eric — New York University School of Medicine
- Study coordinator: Axelrad, Jordan Eric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.