Intestinal chondroitin sulfate glycosaminoglycans and their role in inflammatory bowel disease
Funded at University of Washington · NIH-11406345 · Data updated 2026-11-12
A clinician-scientist mentoring program aims to advance understanding of how intestinal sugar molecules called chondroitin sulfate glycosaminoglycans influence inflammatory bowel disease and patient care.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 15, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $164,268 |
| NIH project number | 5K08DK141910-02 |
| Project ID | NIH-11406345 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with inflammatory bowel disease or those undergoing pediatric gastroenterology evaluations may benefit from insights generated by this research in the future.
✕Less likely to help
Patients not affected by IBD or related intestinal conditions may not directly benefit from this specific training grant.
What this research studies
This five-year training grant supports a clinician-researcher in Pediatrics Gastroenterology to build an independent career studying the extracellular matrix in inflammatory bowel disease. The project will be conducted in collaboration with senior mentors and translational institutes to explore how matrix components affect mucosal biology and inflammation. The trainee will integrate clinical insight with laboratory investigations, using patient-derived samples and relevant models to uncover mechanisms that could inform future therapies. The program emphasizes mentorship, translational training, and the development of independent research aims related to IBD pathophysiology.
Why it matters
Potential benefit: If successful, this work could lead to new molecular targets or biomarkers that improve diagnosis, monitoring, and treatment for people with inflammatory bowel disease.
How similar studies have gone: Prior work in matrix biology and IBD has shown that extracellular matrix components can influence intestinal inflammation, supporting potential translational relevance.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Francis-Stream, Kendra Leigh — University of Washington
- Study coordinator: Francis-Stream, Kendra Leigh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.