IBD risk picture: personal risk and progression in diverse patients
Official title: Integrative and longitudinal multi-omic risk assessment in inflammatory bowel disease progression
Funded at Emory University · NIH-11378027 · Data updated 2026-11-12
A broad study at Emory will look at how genetics, epigenetics, gut bacteria, and lifestyle factors like diet and alcohol influence how inflammatory bowel disease may get worse in people, especially in African American communities.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 30, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $557,918 |
| NIH project number | 5U01DK134191-05 |
| Project ID | NIH-11378027 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are individuals with IBD, particularly African American patients, who consent to long-term follow-up and provide genetic, epigenetic, microbiome, and lifestyle data.
✕Less likely to help
Patients who do not participate or who have limited access to follow-up may not directly benefit.
What this research studies
This project follows people with inflammatory bowel disease to understand why some individuals progress to more severe disease. It combines genetic, epigenetic, microbial, and metabolic data gathered over time to build individualized risk profiles. The study will examine how polygenic risk scores interact with diet, smoking, and alcohol to affect disease trajectory, and how gut microbiome changes relate to outcomes. By integrating these factors, researchers aim to identify markers that predict progression and potential targets for personalized care.
Why it matters
Potential benefit: If successful, the research could lead to personalized risk assessments and tailored interventions to slow or prevent severe disease in patients with IBD.
How similar studies have gone: Previous work has shown that genetics and microbiome composition can influence IBD outcomes, but comprehensive multi-omic and lifestyle integration in diverse populations is still emerging.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Kugathasan, Subra — Emory University
- Study coordinator: Kugathasan, Subra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.