Gut bacteria stability in ulcerative colitis and Crohn’s disease
Official title: The Influence Of Gut Microbiota Stability In Inflammatory Bowel Disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-11296873 · Data updated 2026-11-12
Researchers are tracking gut bacteria over several years in people with ulcerative colitis and Crohn’s disease (and healthy volunteers) to see whether long-term bacterial stability links to flares and outcomes after fecal transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 4, 2019 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $641,450 |
| NIH project number | 5R01DK112978-08 |
| Project ID | NIH-11296873 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with ulcerative colitis or Crohn’s disease, including those who’ve had a fecal microbiota transplant and are in remission, plus healthy volunteers for comparison.
✕Less likely to help
People without inflammatory bowel disease or those needing immediate urgent treatment are unlikely to receive direct benefit from participating.
What this research studies
You would provide stool samples once a year for up to five years so researchers can follow the makeup of your gut bacteria over time. People who received fecal microbiota transplants for ulcerative colitis will be followed after treatment to see which donor strains stick around. The team will use DNA sequencing and laboratory methods to identify which bacterial strains are stable or lost in each person. The goal is to connect patterns of bacterial change with long-term remission or relapse.
Why it matters
Potential benefit: If successful, this work could help predict flares and improve long-term success of fecal transplants by identifying protective or harmful bacterial strains.
How similar studies have gone: Previous studies show fecal transplants can help some people with ulcerative colitis, but long-term tracking of specific bacterial strains to predict relapse is a relatively new approach.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Faith, Jeremiah James — Icahn School of Medicine at Mount Sinai
- Study coordinator: Faith, Jeremiah James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.