Role of microbiota-specific T cells in inflammatory bowel disease
Official title: The role of microbiota specific T cells in Inflammatory Bowel Disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-11340316 · Data updated 2026-11-12
A doctor-science team will study how the body's T cells that recognize gut microbes relate to inflammatory bowel disease in people and in a humanized mouse model.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $726,142 |
| NIH project number | 1R01DK146930-01 |
| Project ID | NIH-11340316 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with Crohn’s disease or other inflammatory bowel diseases who are being considered for anti-IL-23 therapy and healthy controls.
✕Less likely to help
Patients not eligible for anti-IL-23 therapy or those without access to advanced sequencing studies may have no direct benefit.
What this research studies
This project will use cutting-edge single-cell RNA and TCR sequencing to track T cell types and clonotypes over time in people with Crohn's disease who do or don’t respond to anti-IL-23 therapy, compare them with healthy controls, and study similar processes in humanized mice. By following how these T cells change before and after colitis induction, researchers aim to identify specific TCRs and cell states linked to disease activity. The findings could guide the development of targeted, antigen-specific therapies for IBD. The work combines patient samples and advanced animal models to map immune responses at high resolution.
Why it matters
Potential benefit: If successful, this could lead to precision therapies that target disease-causing T cells in IBD, potentially reducing reliance on broad immunosuppressants.
How similar studies have gone: Previous similar approaches identified antigen-specific antibodies and T cell patterns in autoimmune diseases, suggesting this strategy could reveal actionable targets in IBD.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Faith, Jeremiah James — Icahn School of Medicine at Mount Sinai
- Study coordinator: Faith, Jeremiah James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.