Mn in inflammatory bowel disease: how manganese and genes may shape gut inflammation
Official title: Manganese in inflammatory bowel disease
Funded at University of Michigan at Ann Arbor · NIH-11420332 · Data updated 2026-11-12
This grant studies how the mineral manganese and a specific gene variant may influence inflammatory bowel disease in people of different ages.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 24, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $728,096 |
| NIH project number | 5R01DK123022-07 |
| Project ID | NIH-11420332 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with inflammatory bowel disease or those at risk, including adolescents and adults, who can provide genetic/dietary information and biological samples.
✕Less likely to help
Healthy individuals without IBD or related risk factors may not directly benefit from this research.
What this research studies
Researchers at the University of Michigan are exploring how dietary manganese and a genetic variant affect the risk and progression of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. The work builds on prior findings that Mn availability and the SLC39A8 transporter influence gut biology and inflammation. By examining mechanisms linking genetics, diet, and intestinal injury, the study aims to identify potential targets for future therapies. The project involves analyses in humans and animal models to better understand how nutrient-gene interactions may drive IBD in patients.
Why it matters
Potential benefit: If successful, this research could reveal new dietary or therapeutic strategies to reduce inflammation and improve outcomes for people with IBD.
How similar studies have gone: Previous work has shown that manganese levels and genetic variants can influence intestinal injury in animal models, supporting the direction, with human confirmation still advancing.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Seo, Young Ah — University of Michigan at Ann Arbor
- Study coordinator: Seo, Young Ah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.