Gasdermin-based epithelial function in inflammatory bowel disease

Who could benefit from this research

What this research studies

This grant looks at how gasdermin proteins in gut lining cells contribute to mucosal healing and how genetic variants may worsen disease. Researchers will examine the full-length and variant forms of GSDMB and how they interact with immune signals and bacterial exposure in intestinal cells. The work aims to uncover mechanisms in epithelial biology that could point to new ways to support gut barrier function. Results could lead to more targeted therapies that help people with IBD maintain a healthy intestinal lining.

Why it matters

Where this research is happening

• Case Western Reserve University
  Cleveland, United States Active

Researchers

• Principal investigator: Pizarro, Theresa Torres — Case Western Reserve University
• Study coordinator: Pizarro, Theresa Torres

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.