2’-FL for maintaining remission in Crohn’s disease (pediatric and young adults)

Who could benefit from this research

What this research studies

Crohn’s disease often relapses even when patients are in remission on anti-TNF therapy. The study will give 2’-FL or a placebo to pediatric and young adult participants in stable remission to see if it is safe and well tolerated, and whether it increases beneficial gut bacteria and short-chain fats. Participants will take a daily supplement and be monitored for disease activity, GI symptoms, and fecal biomarkers. The research uses a randomized, dose-ranging design to identify safe doses of 1 g or 5 g per day compared with placebo. If successful, this approach could support longer, healthier remission for people living with Crohn’s disease while staying on current therapies.

Why it matters

Where this research is happening

• Cincinnati Childrens Hosp Med Ctr
  Cincinnati, United States Active

Researchers

• Principal investigator: Denson, Lee Armistead — Cincinnati Childrens Hosp Med Ctr
• Study coordinator: Denson, Lee Armistead

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.