Functional roles of IBD genetics in how the body responds to microbes
Official title: Functional outcomes of inflammatory bowel disease associated variants
Funded at Yale University · NIH-11360128 · Data updated 2026-11-12
Scientists are studying how genetic differences in people with inflammatory bowel disease influence how their bodies react to microbes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 18, 2013 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $708,679 |
| NIH project number | 5R01DK099097-13 |
| Project ID | NIH-11360128 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with inflammatory bowel disease who carry certain genetic variants linked to immune responses.
✕Less likely to help
Individuals without IBD or without relevant genetic variants may not benefit from this research.
What this research studies
This project looks at how innate immune pathways, especially pattern recognition receptors, shape inflammation in IBD. By examining multiple genetic variants linked to IBD, researchers aim to map how these differences alter cytokine production and microbial clearance. The goal is to classify individuals based on their genetic impact on immune responses and to uncover central disease mechanisms. The study uses human genetic variation to perturb experimental systems and understand functional consequences.
Why it matters
Potential benefit: Understanding these genetic effects could lead to more personalized insights into IBD risk and potential targets for therapies that modulate the immune response to microbes.
How similar studies have gone: Previous studies have shown that genetic variation can influence PRR pathways and cytokine responses in autoimmunity, supporting the relevance of this approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Abraham, Clara — Yale University
- Study coordinator: Abraham, Clara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.