Condition

Hypoglycemia clinical trials and research

• 19Clinical trials
• 54NIH research projects
• 8Countries

Newest Hypoglycemia clinical trials

All recruiting trials (19)

• Understanding glucagon and sugar metabolism after meals in people with and without PBH after weight-loss surgery

  This study tests how glucagon and post-meal glucose handling differ between people who have post-bariatric surgery hypoglycemia and those who don’t.

  Recruiting at 2 sites Phase 4 Joslin Diabetes Center · Birmingham, Alabama and 1 other locations · NCT07818707

• Fear of hypoglycemia in people with diabetes

  This study looks at how fear of low blood sugar affects how people with diabetes take their medications and manage their diet.

  Recruiting Bilecik Seyh Edebali Universitesi · Bilecik · NCT07329985

• How sexual activity affects low blood sugar risk in adults with insulin-treated diabetes who use a CGM

  This study will see if sexual activity changes the risk of low blood sugar in adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor.

  Recruiting Medical University of Warsaw · Warsaw · NCT07286500

• In-ear blood flow monitoring for people with low blood sugar after weight-loss surgery

  This pilot will try a small in-ear wearable that measures head blood flow in adults with post-bariatric hypoglycemia and compare results to surgical and non-surgical control groups.

  Recruiting Joslin Diabetes Center · Boston, Massachusetts · NCT07082478

• Breath sensor for detecting hypo- and hyperglycemia in teens with type 1 diabetes

  This test checks whether a breath-based VOC sensor can spot low or high blood sugar in 12–19-year-olds with type 1 diabetes who use a Dexcom CGM.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06893341

• Investigating the safety and effectiveness of porcine pancreatic cells in patients with Type 1 diabetes

  This study is testing if using pig pancreas cells can help adults with tough-to-manage Type 1 diabetes feel better and avoid dangerous low blood sugar episodes.

  Recruiting Phase 1/2 Otsuka Pharmaceutical Factory, Inc. · Chicago, Illinois · NCT06575426

• Using continuous glucose monitoring for newborns with brain injury

  This study is testing if using continuous glucose monitoring can help newborns with brain injury keep their blood sugar levels stable and improve their health outcomes.

  Recruiting University of Campania Luigi Vanvitelli · Avellino and 2 other locations · NCT06563687

• C-peptide's effect on blood sugar regulation during hypoglycemia

  This study tests if adding C-peptide to insulin can help people with type 1 diabetes and healthy individuals better manage their blood sugar during low blood sugar episodes.

  Recruiting Early Phase 1 University of Cincinnati · Cincinnati, Ohio · NCT06470295

• Examining how menstruation affects blood sugar control and exercise in women with type 1 diabetes

  This study tests how hormonal changes during the menstrual cycle affect blood sugar control and exercise in women with type 1 diabetes to see if adjusting insulin and food intake can help improve their management.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06297980

• Improving diabetes management for older adults at risk of low blood sugar

  This study tests a new educational program using continuous glucose monitoring to help older adults with type 2 diabetes avoid dangerous low blood sugar levels.

  Recruiting Kaiser Permanente · Fremont, California and 5 other locations · NCT06296485

• Monitoring glucose levels in critically ill patients

  This study looks at how often critically ill patients in the ICU experience low blood sugar and how using continuous glucose monitors can help improve their care.

  Recruiting Universidad Europea de Madrid · Madrid · NCT06234787

• Understanding blood sugar control in patients with Left Ventricular Assist Devices

  This study is trying to see if using a continuous glucose monitor gives better information about blood sugar control than traditional blood tests for people with Left Ventricular Assist Devices and type 2 diabetes.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05933161

• Improving decision-making for patients with dementia and diabetes

  This study is trying to help patients with dementia and diabetes, along with their caregivers, make better decisions by testing a new tool that makes it easier to understand glucose monitoring data.

  Recruiting Indiana University · Indianapolis, Indiana · NCT05643144

• Using a special stent to help reverse gastric bypass surgery

  This study is testing whether a special stent can help people who need their gastric bypass reversed feel better and improve their nutrition without needing surgery.

  Recruiting at 2 sites University Hospital, Ghent · Bruges and 1 other locations · NCT05640947

• Improving diabetes management in hospitals with a decision support tool

  This study is testing a new electronic tool that helps doctors manage blood sugar levels in hospitalized patients with diabetes to see if it improves their care and reduces costs.

  Recruiting at 2 sites Milton S. Hershey Medical Center · Hershey, Pennsylvania and 1 other locations · NCT05447806

• National cohort study of people with type 1 diabetes in France

  This study looks at how changes in blood sugar levels and different insulin treatments affect heart health in people with type 1 diabetes over ten years.

  Recruiting Fondation Francophone pour la Recherche sur le Diabete · Paris · NCT04657783

• Studying how a mother's glucose control during pregnancy affects her baby's glucose levels after birth

  This study looks at how well a mother's blood sugar is controlled during pregnancy to see if it affects her baby's blood sugar levels after birth.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge, Cambridge · NCT04192422

• Investigating how neural and hormonal factors affect insulin secretion after gastric bypass surgery

  This study is trying to see how certain hormones and nerve signals affect insulin release in people who have had gastric bypass surgery, especially looking at those who experience low blood sugar compared to those who don’t and healthy individuals.

  Recruiting at 2 sites Early Phase 1 The University of Texas Health Science Center at San Antonio · San Antonio, Texas and 1 other locations · NCT00992901

• Research on diagnosing and treating low blood sugar levels

  This study is testing how to better diagnose and treat low blood sugar in people with insulinomas while they receive care at a special clinic.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001276

NIH-funded research (newest 40 of 54)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes

  A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.

  NIH research University of Sheffield · Sheffield, United Kingdom · NIH-11603070

• Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes

  A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.

  NIH research University of Sheffield · Sheffield, United Kingdom · NIH-11603069

• Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology

  This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.

  NIH research University of Sheffield · Sheffield, United Kingdom · NIH-11603068

• Helping people with type 1 diabetes regain awareness of dangerous lows

  A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.

  NIH research University of Sheffield · Sheffield, United Kingdom · NIH-11603067

• Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it

  This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11582458

• Glucagon Pump Therapy for PBH in People After Bariatric Surgery

  A new approach uses a patch pump and smart control to deliver glucagon during meal-related lows in adults who had bariatric surgery and developed dangerous hypoglycemia.

  NIH research Joslin Diabetes Center · Boston, United States · NIH-11369636

• Brain blood flow patterns linked to hypoglycemia and thinking problems in diabetes

  A study is testing a new brain-imaging technique to see how recurrent low blood sugar affects brain blood flow and thinking in adults with type 2 diabetes.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11364144

• Astrocyte controls brain blood flow during low blood sugar

  Researchers will study how certain brain support cells (astrocytes) help increase blood flow in the brain when blood sugar drops, using mouse models.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11362532

• Understanding how a MAFA gene variant affects glucose problems differently in men and women

  A study in adult diabetes patients and a mouse model looks at how a rare MAFA gene variant (S64F) may cause diabetes in men and hypoglycemia in women, aiming to explain sex differences in disease risk.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11330210

• Understanding how impaired hypoglycemia awareness develops in type 1 diabetes and how automated insulin delivery and exercise might help restore it

  This study looks at adults with type 1 diabetes who struggle to sense hypoglycemia and tests whether automated insulin delivery and exercise can help restore their awareness.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11322740

• Improving awareness of hypoglycemia in type 1 diabetes with targetted tech and education

  A study tests two treatments to help adults with type 1 diabetes who frequently misread signs of low blood sugar, using technology and education over 12 months with follow-up.

  NIH research University of Sheffield · Sheffield, United Kingdom · NIH-11322615

• Improved insulin systems for adults with type 1 diabetes who don’t notice low blood sugar

  Adults with long-standing type 1 diabetes who often miss low blood sugar will use either an automated hybrid closed-loop insulin system or a sensor-linked insulin pump to see which helps them notice and avoid hypoglycemia.

  NIH research Adventhealth Orlando · Orlando, United States · NIH-11319846

• Using wearables and smart pumps to lower the risk of unrecognized low blood sugar

  This project uses continuous glucose monitors and hybrid closed-loop insulin systems to find people with impaired awareness of hypoglycemia in type 1 diabetes and help restore their ability to notice low blood sugar.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11319806

• Restoring low-blood-sugar awareness in adults with Type 1 diabetes

  This project aims to use modern diabetes technology and care to help adults with Type 1 diabetes who have trouble sensing low blood sugar regain that awareness and stronger bodily responses.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11319785

• Restoring awareness of low blood sugar in type 1 diabetes

  This project tests whether education, hybrid closed-loop insulin pumps, and small doses of glucagon can help adults with long-standing type 1 diabetes regain warning signs of low blood sugar.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11319767

• Restoring the ability to notice low blood sugar in people with type 1 diabetes

  This project helps people with type 1 diabetes who can’t feel low blood sugar avoid lows and try a hybrid closed‑loop insulin system to see if their ability to notice hypoglycemia comes back.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11319759

• Orexin brain cells and loss of low-blood-sugar awareness in diabetes

  Researchers are looking at brain cells called orexin neurons to learn why some people with diabetes stop noticing dangerously low blood sugar.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11293441

• How low leptin levels affect the body's response to low blood sugar

  Looks at whether low leptin levels make the body's natural defenses against low blood sugar weaker in people with diabetes.

  NIH research Lsu Pennington Biomedical Research Ctr · Baton Rouge, United States · NIH-11291860

• Low blood sugar and oxygen-sensing proteins in early diabetic eye disease

  This project tests whether brief drops in blood sugar trigger oxygen-sensing proteins that drive early diabetic eye damage in people with diabetes.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11260228

• How the liver responds during insulin-caused low blood sugar

  Looks at whether giving C‑peptide during insulin‑induced low blood sugar helps the liver raise blood sugar in people with and without type 1 diabetes.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11257359

• A protein that controls insulin signaling and prevents low blood sugar

  This work focuses on a protein called SCAN that may drive insulin resistance in people with type 2 diabetes and aims to restore normal insulin signaling.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11249192

• Preventing dangerous low blood sugar in Veterans with diabetes

  It tests methods to better detect and prevent dangerous low blood sugar in Veterans who have diabetes.

  NIH research Edith Nourse Rogers Memorial Veterans Hospital · Bedford, United States · NIH-11241944

• How brain cells called astrocytes control blood flow during low blood sugar

  This work explores how specialized brain cells called astrocytes help increase blood flow to the brain when blood sugar levels drop too low, a serious issue for people with diabetes.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11160734

• A Glucagon Pump for Low Blood Sugar After Weight Loss Surgery

  This project is developing a special pump that delivers glucagon to help people who experience dangerously low blood sugar after bariatric surgery.

  NIH research Joslin Diabetes Center · Boston, United States · NIH-11146766

• Helping the body make its own glucagon to prevent low blood sugar

  This project looks for new ways to help people with Type 1 Diabetes naturally produce more glucagon to prevent dangerously low blood sugar.

  NIH research Duke University · Durham, United States · NIH-11143928

• Understanding how a brain receptor helps regulate low blood sugar levels

  This study is looking at how a special receptor in the brain helps control low blood sugar levels, and it's using mice to see what happens when this receptor is missing, which could help improve diabetes treatments in the future.

  NIH research University of Kentucky · Lexington, United States · NIH-11133672

• Understanding how a brain receptor helps regulate low blood sugar levels

  This study is looking at how a certain receptor in the brain helps control low blood sugar levels, and it aims to find out what happens when this receptor is missing, which could help us better understand diabetes and how to manage low blood sugar.

  NIH research University of Kentucky · Lexington, United States · NIH-11130342

• Understanding Stroke Risk in Diabetes with Low Blood Sugar

  This project explores how repeated episodes of low blood sugar in people with diabetes might increase their risk and worsen the effects of stroke.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11127425

• Reducing low blood sugar emergencies in adults with Type 1 diabetes using mobile health technology.

  This study is looking to help adults with Type 1 diabetes who use continuous glucose monitors by figuring out what beliefs might be getting in the way of treating low blood sugar, and then creating a helpful mobile app to give them real-time support and education.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11103180

• Investigating a genetic variant's role in diabetes and blood sugar levels based on sex

  This study is looking at how a specific change in a gene affects blood sugar control differently in men and women, using mice to help us understand how it impacts insulin production, which could lead to better, personalized treatments for diabetes.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11094752

• Understanding Brain Changes from Low Blood Sugar in Type 2 Diabetes

  This research explores how repeated episodes of low blood sugar in people with Type 2 diabetes affect their brain and thinking abilities.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11083684

• Comparing treatments to improve awareness of low blood sugar in adults with type 1 diabetes.

  This study is looking at how two different approaches can help adults with type 1 diabetes who have trouble noticing when their blood sugar is too low, and it aims to find out which method works best for different people over the next year or two.

  NIH research University of Sheffield · Sheffield, United Kingdom · NIH-11077200

• Using technology to improve awareness of low blood sugar in type 1 diabetes patients

  This study is looking to help people with type 1 diabetes who have trouble sensing when their blood sugar is low by using special monitoring technology, and it will also see if new management tools can help them regain that awareness.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11077196

• Understanding how to improve awareness of low blood sugar in people with type 1 diabetes

  This study is looking at how using automated insulin delivery systems and doing high-intensity interval exercise can help adults with type 1 diabetes regain their ability to sense when their blood sugar is low, which is really important for staying healthy.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11077195

• Improving awareness of low blood sugar in people with type 1 diabetes

  This study is looking for ways to help people with type 1 diabetes recognize when their blood sugar is low, using different methods like education and new treatments, to keep them safe and healthy over two years.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11076662

• Improving insulin delivery to help people with type 1 diabetes recognize low blood sugar.

  This study is looking at two different ways to deliver insulin to help people with type 1 diabetes who have trouble noticing when their blood sugar is low, and it aims to find out which method works better to keep them safe from low blood sugar episodes while also providing helpful education on managing their condition

  NIH research Adventhealth Orlando · Orlando, United States · NIH-11076628

• Improving awareness of low blood sugar in people with Type 1 Diabetes

  This study is designed to help people with Type 1 Diabetes who have trouble noticing when their blood sugar is low by using new technology and education to keep them safe and better manage their diabetes.

  NIH research University of Kentucky · Lexington, United States · NIH-11076626

• Restoring awareness of low blood sugar in people with type 1 diabetes

  This study is for people with type 1 diabetes who sometimes don't notice when their blood sugar is low, and it will test a program that teaches them how to avoid low blood sugar and uses advanced insulin delivery systems to help them regain that awareness over a year.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11076623

• Improving care planning for older adults with diabetes to prevent low blood sugar events

  This study is looking to improve how older adults with type 2 diabetes, especially those at risk for low blood sugar, can make decisions about their care by using a new online tool that helps them talk about their treatment goals, and it will compare this approach to regular care for people aged 75 and older.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11076453

• Investigating ways to improve awareness of low blood sugar in people with Type 1 Diabetes

  This study is looking for people with Type 1 Diabetes who sometimes don't notice when their blood sugar is low, and it aims to find out how new diabetes management tools can help them feel more aware of their blood sugar levels and stay healthier.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11073004

Related topics

Quick answers

How many Hypoglycemia clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (12 trials), Turkey (Türkiye) (1 trial), Poland (1 trial), Belgium (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 2, Phase 1/2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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