Condition

Type 1 Diabetes (T1D) clinical trials and research

• 48Clinical trials
• 8NIH research projects
• 18Countries

Newest Type 1 Diabetes (T1D) clinical trials

All recruiting trials (48)

• Benefits of Retained Insulin for Good Health in Diabetes

  This study tests whether preserving or restoring a person’s own insulin production can improve quality of life and blood sugar control for people who need insulin to manage diabetes.

  Recruiting at 4 sites Royal Devon and Exeter NHS Foundation Trust · Truro, Cornwall and 3 other locations · NCT07828626

• Intermittent CGM Use in high-risk children and teens with Type 1 Diabetes in the Dominican Republic

  This study tests whether using the Dexcom G7 intermittently, along with pediatric care and support, can improve glucose control in 10–19 year-olds with high-risk Type 1 Diabetes in the Dominican Republic.

  Recruiting at 3 sites Life for a Child Program, Diabetes Australia · Santiago de los Caballeros and 2 other locations · NCT07742306

• AI-assisted remote insulin pump optimization for people with type 1 diabetes

  This study tests an AI-powered tool that suggests insulin pump settings for people with type 1 diabetes, with doctor-approved recommendations delivered to a mobile app.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT07732777

• AMX0035 in adults with Type 1 Diabetes

  This study tests whether 24 weeks of the oral medication AMX0035 help improves metabolic health in adults with Type 1 Diabetes compared with a placebo.

  Recruiting Phase 2 University of Washington · Seattle, Washington and 1 other locations · NCT07699380

• Dietary changes to help adults with Type 1 diabetes and overweight see if moderate carbs, time-restricted eating, or regular calories work

  We’re testing three weight-loss approaches in adults with type 1 diabetes who are overweight or obese to see which helps reduce weight safely.

  Recruiting Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud · Málaga, Málaga · NCT07667504

• Islet re-transplantation after prior graft failure in adults with type 1 diabetes

  This study looks at whether giving another islet transplant after a prior failed graft helps adults with type 1 diabetes who have severe swings in blood sugar.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07666789

• See if a home diabetes screening kit helps people at risk for type 1 diabetes

  This study tests whether email or mail outreach versus phone follow-up more effectively prompts Indiana Biobank participants to complete a Type 1 diabetes home screening kit.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07663136

• Cadisegliatin added to insulin in adults with Type 1 diabetes using hybrid closed loop systems

  This study tests whether cadisegliatin taken once daily can help people with Type 1 diabetes who are already using a hybrid closed-loop insulin pump manage blood sugar better when added to their usual insulin therapy.

  Recruiting at 6 sites Phase 2 vTv Therapeutics · Modesto, California and 5 other locations · NCT07616206

• Safety check of MODI insulin- titration tool in adults with diabetes

  This study tests whether the MODI insulin titration algorithm is safe to use in adults with type 1 or type 2 diabetes who use insulin and CGM.

  Recruiting at 5 sites DreaMed Diabetes · Baltimore, Maryland and 5 other locations · NCT07599982

• Test of NNC0497-0040 in healthy adults, people with overweight/obesity, and adults with type 1 diabetes with overweight

  This study tests whether NNC0497-0040 is safe and tolerable and can help people who are healthy, those with overweight or obesity, and those with type 1 diabetes and overweight or obesity.

  Recruiting Phase 1 Novo Nordisk A/S · Neuss · NCT07578584

• Using continuous glucose monitoring to spot early loss of pancreatic islet transplant function

  This project will see if a CGM measure called Time in Tight Range (70–140 mg/dL) can detect early loss of islet transplant function in adults with insulin-dependent diabetes.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07470593

• Three-stage CGM integration program for older adults with insulin-dependent diabetes

  A program with three CGM-focused training sessions is being tested to see if it helps older adults using insulin wear CGMs more and manage their glucose better compared with standard CGM training.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07463209

• Postmarket monitoring of twiist automated insulin delivery for people with Type 1 diabetes

  This project will collect real-world data from people age 6 and older with Type 1 diabetes who recently started using the twiist automated insulin delivery system to see how it works for them over 12 months.

  Recruiting Deka Research and Development · Tampa, Florida · NCT07356089

• How exercising in hot weather affects blood sugar in people with type 1 diabetes.

  This study will test whether 40 minutes of moderate exercise in hot conditions changes blood sugar during exercise and for 30 minutes afterward in adults with type 1 diabetes.

  Recruiting Liverpool John Moores University · Liverpool · NCT07341243

• CommuniT1D: virtual peer support for adults with type 1 diabetes in Canada

  This project will try a virtual, peer-led support program of small group meetings and webinars for adults in Canada living with type 1 diabetes or related insulin-requiring diabetes and for their loved ones.

  Recruiting Laval University · Québec, Quebec · NCT07317986

• How sexual activity affects low blood sugar risk in adults with insulin-treated diabetes who use a CGM

  This study will see if sexual activity changes the risk of low blood sugar in adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor.

  Recruiting Medical University of Warsaw · Warsaw · NCT07286500

• DailyDose: a smartphone app to help manage type 1 diabetes with personalized insulin and meal tips

  This study tests DailyDose, a smartphone-based decision tool, to see if it can help adults with type 1 diabetes lower their HbA1c by using CGM data, insulin dosing, and exercise information.

  Recruiting at 6 sites Oregon Health and Science University · Los Angeles, California and 5 other locations · NCT07282639

• Comparing how exercise affects blood sugar in adults with and without Type 1 diabetes.

  We will see if a standardized bout of cycling causes similar blood sugar changes within the same person and between people, in adults with Type 1 diabetes and in healthy adults, using continuous glucose monitors and finger‑stick checks.

  Recruiting University College Dublin · Dublin, Dublin · NCT07209930

• A new insulin-sensitizing pill for adults with type 1 diabetes using closed‑loop insulin delivery

  This 12-week test will see if the oral drug CIR-0602K helps adults with type 1 diabetes who use closed-loop insulin systems spend more time in their target glucose range and use less insulin.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT07186660

• Very low-energy ketogenic program for adults with type 1 diabetes and obesity using an automated insulin system

  This will test whether a 4-week very low-energy ketogenic diet delivered with meal replacements can help adults with type 1 diabetes and obesity who use an advanced hybrid closed‑loop insulin system lose weight safely.

  Recruiting Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari · Bari, Italy · NCT07185555

• Community health worker coaches to support automated insulin delivery for Black children with type 1 diabetes

  This program will try having community health workers coach non-Hispanic Black children with type 1 diabetes who use automated insulin delivery to see if it helps their blood sugar control.

  Recruiting University Hospitals Cleveland Medical Center · Cleveland, Ohio · NCT07154251

• UK islet autoantibody registry for early Type 1 diabetes

  This UK registry collects health and antibody information from people with one or more islet autoantibodies to track who develops Type 1 diabetes and to connect them with monitoring or prevention options.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT07125365

• INNODIA Family & Friends Early-Stage Type 1 Diabetes Detection

  This program tests blood autoantibody screening to find people aged 1 to 45 who, because they have a relative or close friend with Type 1 diabetes, may be at higher risk of developing T1D.

  Recruiting at 20 sites INNODIA iVZW · Vienna and 20 other locations · NCT07118098

• Improving blood sugar control in type 1 diabetes using team care, technology, education and peer support

  This program will try whether combining a care team, diabetes technologies (like CGMs and pumps), structured education, and peer support helps people with type 1 diabetes manage their blood sugar better.

  Recruiting at 10 sites Second Xiangya Hospital of Central South University · Beijing, Beijing Municipality and 9 other locations · NCT07097805

• Daily capsules of your own freeze-dried gut bacteria to help preserve insulin-producing cells in recent type 1 diabetes

  This trial tests whether taking daily capsules made from your own freeze-dried stool for six months can help preserve remaining insulin-producing beta cells and improve blood sugar control in adults recently diagnosed with type 1 diabetes.

  Recruiting Phase 2 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT07083882

• Digital mindfulness program for young adults with type 1 diabetes

  This program will test the Calm Health mindfulness app to see if guided digital mindfulness and personalized feedback can help 18–30-year-olds with type 1 diabetes better manage stress, sleep, and blood sugar.

  Recruiting Yale University · New Haven, Connecticut · NCT07062887

• CNK-UT009 cell injection for type 1 diabetes

  This study will test CNK-UT009 cell injections in adults with type 1 diabetes to see if the treatment is safe and can help preserve or improve insulin production.

  Recruiting Zibo Central Hospital · Zibo, Shandong · NCT07051564

• Does dietary knowledge for functional insulin therapy affect eating disorder risk in adults with type 1 diabetes?

  This study will test whether knowing and using the dietary rules for functional insulin therapy changes the risk of eating disorders in adults with type 1 diabetes.

  Recruiting University Hospital, Grenoble · Grenoble · NCT07021456

• iLet Bionic Pancreas started through primary care for adults on insulin

  This project will test whether starting the iLet Bionic Pancreas through primary care helps adults with insulin-treated type 1 or type 2 diabetes lower their A1c more than routine care over 13 weeks.

  Recruiting University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT07011147

• Refining the role of closed-loop insulin therapy versus islet transplantation for unstable type 1 diabetes

  This prospective project will follow people with unstable type 1 diabetes who are candidates for islet transplantation to see how often closed-loop insulin systems fail over 12 months.

  Recruiting at 6 sites University Hospital, Grenoble · Lyon, Auvergne-Rhône-Alpes and 6 other locations · NCT07006272

• Effects of Carob-Enriched Pasta on Blood Sugar Levels in Healthy Individuals and Those with Type 1 Diabetes

  This study is testing if eating pasta made with carob flour can help control blood sugar levels in both healthy people and those with type 1 diabetes.

  Recruiting Federico II University · Naples · NCT06994403

• Education program to improve blood sugar control in adolescents with Type 1 diabetes

  This study is testing an educational program to help Arab adolescents with Type 1 diabetes learn how to better manage their blood sugar levels.

  Recruiting Dasman Diabetes Institute · Kuwait City, Sharq · NCT06984133

• Help adults with type 1 diabetes build and keep regular exercise habits

  This project will try a smartphone app plus personalized coaching, fitness-watch data, and continuous glucose monitoring insights to help adults with type 1 diabetes exercise more often and more confidently.

  Recruiting Yale University · New Haven, Connecticut · NCT06967701

• GNTI-122 cell therapy for adults recently diagnosed with type 1 diabetes

  This test uses an experimental cell therapy made from your own blood, called GNTI-122, to try to preserve insulin production in adults who were recently diagnosed with type 1 diabetes.

  Recruiting at 9 sites Phase 1 GentiBio, Inc · Duarte, California and 9 other locations · NCT06919354

• Using the WARIFA app to promote healthy lifestyles and manage Type 1 Diabetes

  This study is testing whether the WARIFA app can help people with Type 1 Diabetes and those with other health conditions live healthier lives by giving them personalized tips.

  Recruiting Instituto Universitario de Investigaciones Biomédicas y Sanitarias (iUIBS) de la Universidad de Las · Las Palmas de Gran Canaria, Las Palmas · NCT06918444

• Obstructive sleep apnea and blood sugar control in adults with type 1 diabetes

  This project will try nightly CPAP to see if treating obstructive sleep apnea improves blood sugar control in adults with type 1 diabetes who use an insulin pump and continuous glucose monitoring.

  Recruiting University of Chicago · Chicago, Illinois · NCT06915831

• Automated insulin delivery during labor for pregnant people with type 1 diabetes

  This trial will test whether using an automated insulin delivery (AID) system during labor and delivery helps pregnant people with type 1 diabetes keep blood sugar in range, reduces newborn low blood sugar, and improves birth satisfaction compared with IV insulin.

  Recruiting at 3 sites University of California, San Francisco · Los Angeles, California and 2 other locations · NCT06883344

• Testing a home method for glucose tolerance in children with Type 1 Diabetes

  This study tests a new way for kids with Type 1 Diabetes to check their blood sugar at home using a finger prick instead of a needle to see if it's easier and more comfortable.

  Recruiting at 4 sites University of Oxford · Cardiff and 3 other locations · NCT06815081

• Collaborative care program for young adults with Type 1 Diabetes and emotional distress

  This study is testing a new program to see if coaching or education helps young adults with Type 1 Diabetes manage their diabetes and emotional distress better.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06804694

• Using ultrasound to prevent insulin-related fatty lumps in people with diabetes

  This project will try using ultrasound scans in diabetes clinics to find hidden insulin-related fatty lumps (lipohypertrophy) in adults on insulin who use CGM and have variable glucose levels.

  Recruiting Imperial College London · London · NCT06782568

• Single-Session Depression Help for Teens with Type 1 Diabetes

  This study tests whether a one-time depression intervention is feasible and helpful for adolescents with Type 1 diabetes compared with standard diabetes education.

  Recruiting Nemours Children's Health System · Orlando, Florida · NCT06752369

• Monocyte responses in adults with type 1 diabetes and chronic kidney disease

  This study will test whether time-in-range changes how monocytes become activated in adults with type 1 diabetes and chronic kidney disease and whether a GLP-1 drug can reduce that activation in lab tests.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06694558

• Adding the GIP/GLP-1 drug tirzepatide to automated insulin delivery for adults with type 1 diabetes

  This study will test whether once‑weekly tirzepatide added to automated insulin delivery improves blood sugar control in adults with type 1 diabetes.

  Recruiting at 3 sites Phase 3 University of Bern · Chêne-Bougeries, Canton of Geneva and 2 other locations · NCT06630585

• Restoring sleep and circadian timing to improve metabolic health in teens with type 1 diabetes.

  This trial will test whether extending nightly time in bed by an hour plus evening melatonin and morning light can improve insulin sensitivity, blood sugar control, and vascular health in high-school teens (14–19) with type 1 diabetes who usually sleep less than seven hours on school nights.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06627504

• Improving sleep regularity to reduce cardiovascular risks in type 1 diabetes

  This study is trying to see if improving sleep patterns can help adults with type 1 diabetes lower their risk of heart problems.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT06624046

• Virtual group mindfulness or diabetes education for teens with type 1 diabetes and mood symptoms

  This trial tests whether a virtual group mindfulness program or a virtual group diabetes-education program helps teens with type 1 diabetes who have symptoms of depression or anxiety.

  Recruiting Children's National Research Institute · Aurora, Colorado and 1 other locations · NCT06618027

• Investigating the safety and effectiveness of porcine pancreatic cells in patients with Type 1 diabetes

  This study is testing if using pig pancreas cells can help adults with tough-to-manage Type 1 diabetes feel better and avoid dangerous low blood sugar episodes.

  Recruiting Phase 1/2 Otsuka Pharmaceutical Factory, Inc. · Chicago, Illinois · NCT06575426

• Project to improve understanding and treatment of kidney diseases

  This study is trying to find better ways to understand and treat kidney diseases by looking closely at kidney samples and patient data to help create personalized care plans.

  Recruiting at 13 sites Icahn School of Medicine at Mount Sinai · Tucson, Arizona and 12 other locations · NCT04334707

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding brain changes in kids with new Type 1 diabetes

  A multicenter study will follow young children with Type 1 diabetes and similar peers without diabetes to look for factors that influence brain development and thinking skills.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11370335

• Neurocognitive health in young kids with Type 1 diabetes and factors that help or hurt

  A study following young children with Type 1 diabetes to understand how the condition affects thinking skills and behavior, and what factors might protect or worsen these effects.

  NIH research New York University School of Medicine · New York, United States · NIH-11365794

• Understanding Brain Changes in Children with Type 1 Diabetes

  This research aims to understand how Type 1 Diabetes affects brain development and thinking skills in children.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11169695

• Brain Health in Young Children with Type 1 Diabetes

  This project looks at how Type 1 Diabetes affects brain development and thinking skills in young children.

  NIH research New York University School of Medicine · New York, United States · NIH-11168864

• Improving access to continuous glucose monitoring for children with type 1 diabetes.

  This study is looking at how things like race and income affect whether kids with type 1 diabetes can use continuous glucose monitors (CGMs), and it aims to find ways to make sure all children have better access to this helpful technology for managing their diabetes.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11089505

• Investigating how type 1 diabetes affects brain development in young children

  This study is looking at how type 1 diabetes affects the brain and thinking skills in young kids, and it’s inviting children with diabetes and those without to help us learn more by doing some fun brain tests and scans over a couple of years.

  NIH research New York University School of Medicine · New York, United States · NIH-10975293

• Understanding how Type 1 Diabetes affects brain development in children

  This study is looking at how Type 1 Diabetes affects the thinking skills of young kids, exploring how things like high blood sugar can impact their brain development, so we can better understand and support children who might struggle with attention, learning, and memory.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10974858

• Improving diabetes technology use in young adults with type 1 diabetes from minority groups

  This study is looking at how community health workers can help young adults from underrepresented groups with type 1 diabetes use helpful technology like insulin pumps and glucose monitors, making it easier for them to manage their condition and stay healthy.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-10811580

Related topics

Quick answers

How many Type 1 Diabetes (T1D) clinical trials are recruiting right now?

48, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (22 trials), United Kingdom (5 trials), France (5 trials), Italy (3 trials), China (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 2, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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