Condition

Hyperglycemia clinical trials and research

• 30Clinical trials
• 24NIH research projects
• 1New in 30 days
• 14Countries

Newest Hyperglycemia clinical trials

All recruiting trials (30)

• Maltodextrin vs Sugar Water for Pre-Surgery Carbohydrate Loading in Older Adults

  This study tests whether a maltodextrin drink before surgery leaves less fluid in the stomach than sugar water for adults 60 and older undergoing leg surgery with spinal or epidural anesthesia.

  Recruiting Udayana University · Denpasar, Bali · NCT07872683

• Managing pasireotide-related high blood sugar in acromegaly with a ketogenic diet

  This study tests whether a very-low carbohydrate ketogenic diet can help lower HbA1c and fasting glucose in adults with acromegaly who develop high blood sugar while taking pasireotide.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT07866846

• Risk-stratified management of inavolisib-induced hyperglycemia in breast cancer patients

  This observational study tests whether using a pre-treatment risk-stratified plan to manage high blood sugar from inavolisib helps patients stay on therapy.

  Recruiting Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT07817056

• Miniature breath sensors to detect hypo- and hyperglycemia in young people with diabetes

  A small breath-sensor device will try to see if specific breath compounds can signal low or high blood sugar in youths with diabetes.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07696273

• Personality Traits and Biochemical Risk Markers in Routine Health Assessments

  This study tests whether personality traits relate to the number of abnormal lab results found during a standard health checkup in adults.

  Recruiting Medical Center TOPMED · Târgu Mureş, Mureș County · NCT07653048

• Community-based exercise and lifestyle program for people at risk of metabolic syndrome

  A community program tests whether a structured exercise and lifestyle plan can improve heart and blood health in people with hypertension, high cholesterol, or high blood sugar.

  Recruiting Fu Jen Catholic University · New Taipei City · NCT07578090

• Short versus long intermittent hypoxic-hyperoxic training for people with type 2 diabetes, including older adults

  This study will see if short (3-day) or longer (10-day) sessions of intermittent low-oxygen/high-oxygen breathing improve blood sugar control in people aged 50–74 with type 2 diabetes.

  Recruiting National Medical Research Center for Therapy and Preventive Medicine · Moscow · NCT07574333

• Exercise-prescription mini-program for people with high blood pressure, high blood sugar, high cholesterol, or high uric acid.

  This study will try a digital exercise-prescription mini-program to help adults with one or more of the 'Four Highs' increase physical activity and improve related health measures over six months in primary care.

  Recruiting China National Center for Cardiovascular Diseases · Beijing · NCT07400549

• TQF3250 capsules in healthy adults

  Test TQF3250 capsules, a biased GLP-1 receptor agonist, in healthy Chinese adults to see how the drug behaves in the body and whether it is safe and well tolerated.

  Recruiting Phase 1 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Nanjing, Jiangsu · NCT07327281

• Real-time app and wearable sensors to help young people control type 2 diabetes

  This project will try a smartphone app together with a continuous glucose monitor and a Fitbit for English-speaking 16–24-year-olds diagnosed with type 2 diabetes before age 18 to learn which messages and features help with activity and glucose monitoring.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07270016

• Ear (auricular) vagus nerve stimulation to lower inflammation after long spinal fusion

  This trial will test whether non-invasive ear-based vagus nerve stimulation can lower inflammation, improve blood sugar control, and reduce pain after long-segment spinal fusion surgery.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07218133

• Breath sensor for detecting hypo- and hyperglycemia in teens with type 1 diabetes

  This test checks whether a breath-based VOC sensor can spot low or high blood sugar in 12–19-year-olds with type 1 diabetes who use a Dexcom CGM.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06893341

• Using continuous glucose monitors for diabetes management after hospital discharge

  This study is testing if using continuous glucose monitors can help adults with diabetes manage their blood sugar better after leaving the hospital.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06852950

• Monitoring blood glucose in pregnant women receiving betamethasone for fetal lung development

  This study looks at how the medication betamethasone affects blood sugar levels in pregnant women who don't have diabetes but are at risk of preterm birth.

  Recruiting University of Aarhus · Aarhus, Central Region Denmark · NCT06794307

• Investigating body fat distribution and its impact on metabolic diseases in Japanese adults

  This study looks at how the way body fat is distributed affects the risk of metabolic and heart diseases in Japanese adults.

  Recruiting Osaka Metropolitan University · Sakai, Osaka · NCT06694012

• Improving health behaviors in emergency patients with high blood sugar

  This study is testing whether giving educational materials to emergency patients with high blood sugar can help them understand diabetes better and improve their health habits.

  Recruiting at 2 sites Rutgers, The State University of New Jersey · New Brunswick, New Jersey and 1 other locations · NCT06663813

• Using continuous glucose monitoring for newborns with brain injury

  This study is testing if using continuous glucose monitoring can help newborns with brain injury keep their blood sugar levels stable and improve their health outcomes.

  Recruiting University of Campania Luigi Vanvitelli · Avellino and 2 other locations · NCT06563687

• Investigating the link between early high blood sugar and shunt dependency after brain hemorrhage

  This study is trying to see if high blood sugar levels in patients with a brain hemorrhage affect their need for a special drainage device after treatment.

  Recruiting at 3 sites Cantonal Hospital of St. Gallen · Aarau and 2 other locations · NCT06486909

• Comparing continuous glucose monitoring to fingerstick blood sugar checks

  This study tests if a continuous glucose monitoring system can help adult surgical patients manage their blood sugar better than traditional fingerstick tests.

  Recruiting at 2 sites Odense University Hospital · Køge, Køge and 1 other locations · NCT06473480

• Real-time engagement app to improve glycemic control in adolescents and young adults with type 2 diabetes

  A smartphone app that combines glucose, activity, and diet data is tested to see if it helps teens and young adults with type 2 diabetes manage their blood sugar better.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06375460

• Monitoring glucose levels in critically ill patients

  This study looks at how often critically ill patients in the ICU experience low blood sugar and how using continuous glucose monitors can help improve their care.

  Recruiting Universidad Europea de Madrid · Madrid · NCT06234787

• Monitoring glucose levels in women after gestational diabetes

  This study is testing if wearing a continuous glucose monitor can help women who had gestational diabetes keep track of their blood sugar levels after giving birth.

  Recruiting Ohio State University · Columbus, Ohio · NCT06184373

• Eating window timing to improve blood sugar in adults with obesity and type 2 diabetes or at risk

  This study tests whether eating only during one of three nine-hour daily windows can improve blood sugar control in adults with obesity who have or are at risk for type 2 diabetes.

  Recruiting University of Toronto · Toronto, Ontario · NCT06118931

• Understanding blood sugar control in patients with Left Ventricular Assist Devices

  This study is trying to see if using a continuous glucose monitor gives better information about blood sugar control than traditional blood tests for people with Left Ventricular Assist Devices and type 2 diabetes.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05933161

• Zinc supplementation's effect on blood sugar levels in prediabetics

  This study is testing if taking zinc supplements can help lower blood sugar levels in people with prediabetes.

  Recruiting Phase 4 University of Maryland, Baltimore · Lancaster, Pennsylvania · NCT05835037

• Using semaglutide to manage high blood sugar after kidney transplants

  This study is testing if semaglutide can help manage high blood sugar in people who have recently had a kidney transplant, while also looking at its effects on weight and kidney function.

  Recruiting Phase 4 Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT05702931

• Improving diabetes management in hospitals with a decision support tool

  This study is testing a new electronic tool that helps doctors manage blood sugar levels in hospitalized patients with diabetes to see if it improves their care and reduces costs.

  Recruiting at 2 sites Milton S. Hershey Medical Center · Hershey, Pennsylvania and 1 other locations · NCT05447806

• Integrated diagnosis and treatment for chronic kidney disease outcomes

  This study is trying to see if a combined approach to diagnosing and treating chronic kidney disease can help patients manage their health better and improve their overall outcomes.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT05242055

• Managing glucose levels in pancreatic cancer patients

  This study is testing if closely managing blood sugar levels can help people with pancreatic cancer who are receiving standard chemotherapy feel better and improve their treatment outcomes.

  Recruiting at 2 sites British Columbia Cancer Agency · Vancouver, British Columbia and 1 other locations · NCT05132244

• Using a glucose measurement system in intensive care for patients with shock

  This study is testing a new glucose monitoring system to see if it can help make checking blood sugar easier and more comfortable for patients in intensive care who are dealing with septic shock.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice · NCT04910841

NIH-funded research (24)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Cardiovascular health in the offspring of pregnancies affected by gestational glucose and weight

  This study follows young adults whose mothers had gestational diabetes or related conditions to understand how pregnancy health affects their heart and blood vessel health over time.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11529770

• Hyperglycemia, Leukotriene Pathways, and Severe Infections in Diabetes

  A hospital-based research project will explore why high blood sugar makes infections more dangerous for people with diabetes, focusing on inflammatory pathways and a key chemical messenger.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11348253

• Red blood cells and glucose problems after a stroke

  This research looks at how red blood cells behave during and after a stroke when blood sugar is high, and what that means for recovery.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11325093

• Intergenerational heart health: studying how a mother's gestational health affects offspring cardiovascular risk

  This grant studies how a mother’s health during pregnancy may influence her child’s heart health in young adulthood.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11294335

• How the protein Arrdc4 may link high blood sugar to heart damage in diabetes

  This research looks at whether a protein called Arrdc4 causes stress in heart cells when blood sugar is high and so helps explain heart damage in adults with diabetes.

  NIH research City College of New York · New York, United States · NIH-11252891

• Role of a genetic variant in MAFLD and diabetes among African Americans

  A study aims to understand how a specific gene variant (rs142619613) may contribute to fatty liver disease and high blood sugar in African American adults.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11202675

• Investigating how red blood cells affect high blood sugar after a stroke

  This study is looking at how high blood sugar affects red blood cells in stroke patients, to see if these changes make it harder for them to recover and to find new ways to help improve their healing.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11146718

• How high blood sugar affects infections caused by Staphylococcus aureus.

  This study is looking at how high blood sugar levels in people with diabetes can make infections, especially from Staphylococcus aureus, more serious by causing the body’s immune system to react too strongly, and it hopes to find ways to help improve infection treatment for those with diabetes.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11128658

• Understanding diabetes risk in women with Turner syndrome

  This study is looking into why women with Turner syndrome are more likely to develop diabetes, focusing on how their genes and body work together, and it will help us learn more about their health risks related to blood sugar levels.

  NIH research University of Iowa · Iowa City, United States · NIH-11097306

• Investigating how a gene variant affects diabetes and liver disease in African Americans

  This study is looking at how a certain gene variant affects the risk of developing type 2 diabetes and fatty liver disease, especially in African American communities, and it invites patients to share their genetic samples or health information to help uncover how this variant influences insulin and sugar processing in

  NIH research University of Minnesota · Minneapolis, United States · NIH-11085899

• Understanding how tuberculosis affects blood sugar and metabolism

  This study is looking at how having tuberculosis might affect your blood sugar and increase the risk of diabetes over time, and it's for people who have had tuberculosis and want to understand how it could impact their health after treatment.

  NIH research Emory University · Atlanta, United States · NIH-11064045

• Investigating how maternal health during pregnancy affects the heart health of their children.

  This study is looking at how a mother's high blood sugar during pregnancy might affect her child's heart health as they grow up, and it's for young adults who want to understand their own health better.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11047566

• Understanding how high blood sugar affects brain function and behavior

  This study is looking at how high blood sugar affects the brain and behavior in people with depression, especially those with diabetes, to help create better, personalized treatments for them.

  NIH research Baylor University · Waco, United States · NIH-11042379

• How stress-related high blood sugar affects tuberculosis treatment and diabetes risk

  This study is looking at how stress-related high blood sugar affects the treatment of tuberculosis (TB) and whether it increases the chances of developing diabetes afterward, specifically for patients in places like Georgia where both conditions are common.

  NIH research Emory University · Atlanta, United States · NIH-11042238

• Understanding how high blood sugar affects heart cells in diabetes

  This study is looking at how a protein called Arrdc4 affects heart cells when blood sugar levels are high, which can help us find new ways to keep hearts healthier for people with diabetes.

  NIH research City College of New York · New York, United States · NIH-11009543

• Investigating how high blood sugar in mothers affects heart development in babies

  This study is looking at how high blood sugar in pregnant women might affect their babies' heart development, using special cells to see how sugar levels can impact heart cell health and function.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11001107

• How high blood sugar affects immune cells in breast cancer

  This study is looking at how high blood sugar levels might affect the immune system in people with triple-negative breast cancer, especially how it can weaken important immune cells that help fight tumors and boost cells that calm down the immune response, with the goal of finding new ways to improve treatment for brea

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10912497

• Understanding how high blood sugar affects the aorta and its recovery

  This study is looking at how long-term high blood sugar affects a key artery in the body and whether getting blood sugar back to normal can help fix any damage, which could lead to better heart health for people with diabetes.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10900173

• How high blood sugar affects lung infections caused by bacteria

  This study is looking at how high blood sugar levels affect lung infections caused by a specific bacteria, which can make breathing problems worse, especially for people with diabetes, to help find better ways to treat these infections.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10849775

• Understanding high blood sugar levels in surgery patients

  This study is looking at why some people have higher blood sugar levels during and after surgery, even if they don't have diabetes, and it aims to find ways to help patients recover better by understanding how stress affects their blood sugar.

  NIH research Emory University · Atlanta, United States · NIH-10839901

• Exploring time-restricted eating as an alternative to calorie counting for managing type 2 diabetes

  This study is looking at whether eating only during certain hours of the day can help people with type 2 diabetes who are overweight, and who take metformin, to better manage their blood sugar and lose weight, compared to counting calories.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10825524

• Maternal diabetes affects heart development in offspring

  This study looks at how high blood sugar in pregnant women with diabetes might cause heart problems in their babies, focusing on important cells that help the heart develop, and aims to find ways to keep those babies healthier.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-10687863

• How diabetes affects inflammation and infection around dental implants

  This study is looking at how high blood sugar from diabetes might lead to gum problems around dental implants, and it aims to find ways to prevent these issues for people with diabetes by understanding the bacteria in their mouths better.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-10668057

• The link between high blood sugar, hearing loss, and balance problems in older adults

  This study is looking at how high blood sugar levels in people with diabetes might affect hearing and balance in older adults, and it aims to help find ways to catch these issues early so that people can maintain a better quality of life.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10458672

Related topics

Quick answers

How many Hyperglycemia clinical trials are recruiting right now?

30, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (11 trials), China (4 trials), Denmark (3 trials), Canada (2 trials), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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