Improved insulin systems for adults with type 1 diabetes who don’t notice low blood sugar
Advanced Insulin Delivery to Reduce Impaired Awareness of Hypoglycemia in a T1D Cohort (AIDRIAHT1C)
Adults with long-standing type 1 diabetes who often miss low blood sugar will use either an automated hybrid closed-loop insulin system or a sensor-linked insulin pump to see which helps them notice and avoid hypoglycemia.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Adventhealth Orlando NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project ID | NIH-11319846 on NIH RePORTER |
What this research studies
You would join if you are an adult with type 1 diabetes for at least ten years and have reduced awareness of low blood sugar as measured by the HYPO score. Participants who meet that definition are randomly assigned 1:1 to a hybrid closed-loop (HCL) insulin delivery system or to sensor-augmented pump (SAP) therapy. Both groups receive a targeted education program aimed at reducing hypoglycemia, and continuous glucose monitoring and pump data will be used to measure time spent in low glucose and changes in awareness. The study also looks at counter-regulatory responses and brain-related changes linked to impaired awareness.
Who could benefit from this research
Good fit: Adults (21+) with type 1 diabetes of at least ten years’ duration who score positive for impaired awareness of hypoglycemia on the HYPO score are ideal candidates.
Not a fit: People without impaired hypoglycemia awareness, with very recent-onset type 1 diabetes, or unwilling/unable to use pumps and continuous glucose monitors are unlikely to benefit from joining.
Why it matters
Potential benefit: If successful, the approach could help people with impaired hypoglycemia awareness notice lows sooner and reduce dangerous severe hypoglycemic episodes.
How similar studies have performed: Hybrid closed-loop systems have already lowered time in hypoglycemia in prior trials, but using them specifically to restore hypoglycemia awareness and counter-regulatory responses is a newer application.
Where this research is happening
Orlando, United States
- Adventhealth Orlando — Orlando, United States (Active)
Researchers
- Principal investigator: Pratley, Richard E — Adventhealth Orlando
- Study coordinator: Pratley, Richard E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.