Restoring the ability to notice low blood sugar in people with type 1 diabetes
University of Minnesota Clinical Center for the Restoration of Impaired Awareness of Hypoglycemia in Type 1 Diabetes
This project helps people with type 1 diabetes who can’t feel low blood sugar avoid lows and try a hybrid closed‑loop insulin system to see if their ability to notice hypoglycemia comes back.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11319759 on NIH RePORTER |
What this research studies
You would be invited to join a randomized trial enrolling about 650 people with type 1 diabetes who have impaired awareness of hypoglycemia. For 12 months, some participants will receive focused hypoglycemia‑avoidance education plus a hybrid closed‑loop insulin delivery system while others receive current standard care. The research team will track blood glucose, hormone responses, metabolic tests, and questionnaires to find out which factors (for example age, diabetes duration, and glucose patterns) are linked to regaining awareness. The University of Minnesota center is part of a consortium coordinating the protocol and standardized testing across participating sites.
Who could benefit from this research
Good fit: Ideal candidates are people with type 1 diabetes who have impaired awareness of hypoglycemia or a history of recurrent severe lows and who can use continuous glucose monitoring and insulin delivery devices.
Not a fit: People without impaired hypoglycemia awareness, those with type 2 diabetes, or those unable/unwilling to use pump/CGM technology are unlikely to benefit from this trial.
Why it matters
Potential benefit: If successful, the approach could help people with impaired awareness of hypoglycemia regain warning symptoms, lower the risk of severe lows, and improve safe glucose control.
How similar studies have performed: Previous work shows hypoglycemia avoidance and hybrid closed‑loop systems reduce low blood‑sugar events, but restoring awareness varies between people, so this trial builds on prior successes to find who benefits.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Seaquist, Elizabeth R. — University of Minnesota
- Study coordinator: Seaquist, Elizabeth R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.