Improving insulin delivery to help people with type 1 diabetes recognize low blood sugar.
Advanced Insulin Delivery to Reduce Impaired Awareness of Hypoglycemia in a T1D Cohort (AIDRIAHT1C)
This study is looking at two different ways to deliver insulin to help people with type 1 diabetes who have trouble noticing when their blood sugar is low, and it aims to find out which method works better to keep them safe from low blood sugar episodes while also providing helpful education on managing their condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Adventhealth Orlando NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project ID | NIH-11076628 on NIH RePORTER |
What this research studies
This research focuses on enhancing insulin delivery methods to help individuals with type 1 diabetes (T1D) who struggle to recognize low blood sugar levels, a condition known as impaired awareness of hypoglycemia (IAH). The study will compare two advanced insulin delivery systems: hybrid closed-loop (HCL) therapy and sensor-augmented pump (SAP) therapy, to see which is more effective in reducing hypoglycemia episodes. Participants will receive targeted education to further support their management of blood sugar levels. The goal is to improve awareness of hypoglycemia and the body's response to low blood sugar.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with type 1 diabetes who have had the condition for at least ten years and experience impaired awareness of hypoglycemia.
Not a fit: Patients who do not have type 1 diabetes or those who do not experience impaired awareness of hypoglycemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the safety and quality of life for individuals with type 1 diabetes by reducing the risk of severe hypoglycemia.
How similar studies have performed: Previous research has shown that advanced insulin delivery systems can improve glycemic control, making this approach promising but still requiring further investigation.
Where this research is happening
Orlando, United States
- Adventhealth Orlando — Orlando, United States (Active)
Researchers
- Principal investigator: Pratley, Richard E — Adventhealth Orlando
- Study coordinator: Pratley, Richard E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.