Improving insulin delivery to help people with type 1 diabetes recognize low blood sugar.
Official title: Advanced Insulin Delivery to Reduce Impaired Awareness of Hypoglycemia in a T1D Cohort (AIDRIAHT1C)
Funded at Adventhealth Orlando · NIH-11076628 · Data updated 2026-11-12
This study is looking at two different ways to deliver insulin to help people with type 1 diabetes who have trouble noticing when their blood sugar is low, and it aims to find out which method works better to keep them safe from low blood sugar episodes while also providing helpful education on managing their condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Adventhealth Orlando NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project start | September 25, 2022 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $328,315 |
| NIH project number | 5U01DK135131-03 |
| Project ID | NIH-11076628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with type 1 diabetes who have had the condition for at least ten years and experience impaired awareness of hypoglycemia.
✕Less likely to help
Patients who do not have type 1 diabetes or those who do not experience impaired awareness of hypoglycemia may not benefit from this research.
What this research studies
This research focuses on enhancing insulin delivery methods to help individuals with type 1 diabetes (T1D) who struggle to recognize low blood sugar levels, a condition known as impaired awareness of hypoglycemia (IAH). The study will compare two advanced insulin delivery systems: hybrid closed-loop (HCL) therapy and sensor-augmented pump (SAP) therapy, to see which is more effective in reducing hypoglycemia episodes. Participants will receive targeted education to further support their management of blood sugar levels. The goal is to improve awareness of hypoglycemia and the body's response to low blood sugar.
Why it matters
Potential benefit: If successful, this research could significantly improve the safety and quality of life for individuals with type 1 diabetes by reducing the risk of severe hypoglycemia.
How similar studies have gone: Previous research has shown that advanced insulin delivery systems can improve glycemic control, making this approach promising but still requiring further investigation.
Where this research is happening
-
Adventhealth Orlando
Orlando, United States Active
Researchers
- Principal investigator: Pratley, Richard E — Adventhealth Orlando
- Study coordinator: Pratley, Richard E
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
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Glucagon Pump Therapy for PBH in People After Bariatric Surgery
A new approach uses a patch pump and smart control to deliver glucagon during meal-related lows in adults who had bariatric surgery and developed dangerous hypoglycemia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.