Improving awareness of low blood sugar in people with Type 1 Diabetes
Official title: Restoration of Impaired Awareness of Hypoglycemia U01 Consortium: University of Kentucky
Funded at University of Kentucky · NIH-11076626 · Data updated 2026-11-12
This study is designed to help people with Type 1 Diabetes who have trouble noticing when their blood sugar is low by using new technology and education to keep them safe and better manage their diabetes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | September 25, 2022 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $530,098 |
| NIH project number | 5U01DK135111-03 |
| Project ID | NIH-11076626 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with Type 1 Diabetes who have experienced episodes of hypoglycemia and have impaired awareness of these events.
✕Less likely to help
Patients who do not have Type 1 Diabetes or those who have well-controlled blood sugar levels without hypoglycemia may not benefit from this research.
What this research studies
This research focuses on helping individuals with Type 1 Diabetes (T1D) who experience impaired awareness of hypoglycemia, a condition where they cannot recognize low blood sugar levels. The study will involve a clinical consortium across 10 sites, utilizing advanced diabetes management technologies like hybrid closed-loop insulin pumps and continuous glucose monitors, combined with intensive education on avoiding hypoglycemia. By assessing various factors that affect awareness and response to low blood sugar, the research aims to enhance patient safety and improve overall diabetes management.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of severe hypoglycemic episodes and improve the quality of life for individuals with Type 1 Diabetes.
How similar studies have gone: Previous research has shown that advanced diabetes management technologies can improve blood sugar control and awareness of hypoglycemia, suggesting a promising approach in this area.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Fisher, Simon J — University of Kentucky
- Study coordinator: Fisher, Simon J
Related research
Other NIH-funded projects on the same topics.
-
Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
-
Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
-
Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
-
Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
-
Glucagon Pump Therapy for PBH in People After Bariatric Surgery
A new approach uses a patch pump and smart control to deliver glucagon during meal-related lows in adults who had bariatric surgery and developed dangerous hypoglycemia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.