Understanding how to improve awareness of low blood sugar in people with type 1 diabetes
Official title: Characterizing the evolution of impaired hypoglycemia awareness in people with type 1 diabetes and the impact of automated insulin delivery and exercise on restoring hypoglycemia awareness
Funded at University of Melbourne · NIH-11077195 · Data updated 2026-11-12
This study is looking at how using automated insulin delivery systems and doing high-intensity interval exercise can help adults with type 1 diabetes regain their ability to sense when their blood sugar is low, which is really important for staying healthy.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Melbourne NIH-funded |
| Lab location | 1 site (Melbourne, Australia) |
| Project start | September 25, 2022 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $504,457 |
| NIH project number | 5U01DK135122-03 |
| Project ID | NIH-11077195 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with type 1 diabetes who experience impaired hypoglycemia awareness.
✕Less likely to help
Patients who do not have type 1 diabetes or those who do not experience issues with hypoglycemia awareness may not benefit from this research.
What this research studies
This research investigates the problem of impaired hypoglycemia awareness (IAH) in adults with type 1 diabetes, which can lead to severe health risks. The study will explore how automated insulin delivery systems and high-intensity interval exercise can help restore awareness of low blood sugar levels. By conducting a randomized-controlled trial, researchers aim to understand the evolution of IAH and the effectiveness of these interventions over time. Participants will be monitored to assess changes in their hypoglycemia awareness and overall health.
Why it matters
Potential benefit: If successful, this research could significantly improve the safety and quality of life for individuals with type 1 diabetes by restoring their awareness of low blood sugar.
How similar studies have gone: While there have been limited successes with similar interventions, this research aims to provide new insights and potentially more effective strategies for managing impaired hypoglycemia awareness.
Where this research is happening
-
University of Melbourne
Melbourne, Australia Active
Researchers
- Principal investigator: O'neal, David Norman — University of Melbourne
- Study coordinator: O'neal, David Norman
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
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Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
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Understanding how impaired hypoglycemia awareness develops in type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study looks at adults with type 1 diabetes who struggle to sense hypoglycemia and tests whether automated insulin delivery and exercise can help restore their awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.