Understanding how a brain receptor helps regulate low blood sugar levels
Official title: Role of Hypothalamic Adgrl1 in Counteracting Hypoglycemia
Funded at University of Kentucky · NIH-11130342 · Data updated 2026-11-12
This study is looking at how a certain receptor in the brain helps control low blood sugar levels, and it aims to find out what happens when this receptor is missing, which could help us better understand diabetes and how to manage low blood sugar.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | June 17, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $538,354 |
| NIH project number | 1R01DK140148-01A1 |
| Project ID | NIH-11130342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who experience episodes of low blood sugar.
✕Less likely to help
Patients who do not have diabetes or do not experience hypoglycemia may not benefit from this research.
What this research studies
This research investigates the role of a specific receptor in the hypothalamus, known as Adgrl1, which is crucial for managing low blood sugar levels. The study aims to understand how this receptor influences the body's response to hypoglycemia by examining its effects on brain neurons. Researchers will use animal models to explore how the absence of this receptor affects blood sugar regulation and the body's ability to respond to low glucose levels. The findings could provide insights into the mechanisms behind diabetes and hypoglycemia management.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating hypoglycemia in patients with diabetes.
How similar studies have gone: Previous research has shown that targeting specific receptors in the brain can improve blood sugar regulation, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Chhabra, Kavaljit H — University of Kentucky
- Study coordinator: Chhabra, Kavaljit H
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.