Understanding Stroke Risk in Diabetes with Low Blood Sugar
Official title: Cerebral ischemia and exposure to recurrent hypoglycemia in diabetes
Funded at University of Miami School of Medicine · NIH-11127425 · Data updated 2026-11-12
This project explores how repeated episodes of low blood sugar in people with diabetes might increase their risk and worsen the effects of stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 1, 2021 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $411,355 |
| NIH project number | 5R01NS122808-05 |
| Project ID | NIH-11127425 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is relevant to patients with type 1 or type 2 diabetes who experience recurrent low blood sugar episodes and are at risk for stroke.
✕Less likely to help
Patients without diabetes or those who do not experience recurrent hypoglycemia would likely not directly benefit from this specific line of research.
What this research studies
We know that diabetes increases the risk and severity of stroke, and intensive treatments for diabetes can sometimes lead to low blood sugar. This work looks at how these low blood sugar episodes might make blood clots more likely to form and cause more damage during a stroke. By understanding these connections, we hope to find ways to protect the brain health of people living with diabetes. Our goal is to uncover the specific ways low blood sugar affects the body to make stroke worse.
Why it matters
Potential benefit: If successful, this work could lead to new strategies to reduce stroke severity and incidence for patients with diabetes, improving their long-term brain health.
How similar studies have gone: Epidemiological and clinical studies have highlighted the link between diabetes, intensive therapy, hypoglycemia, and stroke, but the specific mechanisms explored here are being further clarified.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Dave, Kunjan R — University of Miami School of Medicine
- Study coordinator: Dave, Kunjan R
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
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Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
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Understanding how impaired hypoglycemia awareness develops in type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study looks at adults with type 1 diabetes who struggle to sense hypoglycemia and tests whether automated insulin delivery and exercise can help restore their awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.