C-peptide's effect on blood sugar regulation during hypoglycemia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how C-peptide influences glucagon secretion and hepatic glucose production during insulin-induced hypoglycemia in individuals with type 1 diabetes (T1D) and healthy controls. The research involves administering C-peptide alongside insulin to assess its impact on counterregulatory hormone levels and endogenous glucose production. Two separate hypoglycemic clamp studies will be conducted: one with healthy subjects and another with T1D patients, comparing the effects of C-peptide infusion to saline. The goal is to better understand the potential benefits of C-peptide in managing hypoglycemia in T1D.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* BMI less than 30 kg/m2

Exclusion Criteria:

* pregnant or lactating women cigarette smoking presence of HIV or hepatitis presence of cardiovascular disease presence of microvascular disease

Where it's running

• University of Cincinnati
  Cincinnati, Ohio, United States Recruiting

Study contacts

• Principal investigator: Jason Winnick, PhD — University of Cincinnati
• Study coordinator: Jason Winnick, PhD
• Email: jason.winnick@uc.edu
• Phone: 513-558-4437

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.