Comparing treatments to improve awareness of low blood sugar in adults with type 1 diabetes.
Official title: Utilizing an RCT Approach to Compare the Efficacy and Sustainability of Technological and Psycho-Educational Interventions to Improve Impaired Awareness of Hypoglycemia in Type 1 Diabetes.
Funded at University of Sheffield · NIH-11077200 · Data updated 2026-11-12
This study is looking at how two different approaches can help adults with type 1 diabetes who have trouble noticing when their blood sugar is too low, and it aims to find out which method works best for different people over the next year or two.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Sheffield NIH-funded |
| Lab location | 1 site (Sheffield, United Kingdom) |
| Project start | September 25, 2022 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $496,470 |
| NIH project number | 5U01DK135119-03 |
| Project ID | NIH-11077200 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older with type 1 diabetes who experience impaired awareness of hypoglycemia.
✕Less likely to help
Patients who do not have type 1 diabetes or those who do not experience impaired awareness of hypoglycemia may not benefit from this research.
What this research studies
This research investigates how different interventions can help adults with type 1 diabetes who have impaired awareness of hypoglycemia, a condition where individuals do not recognize when their blood sugar is dangerously low. The study will involve two randomized controlled trials that compare a hybrid closed-loop insulin delivery system with blood glucose awareness training. Participants will be monitored over a period of 12 to 24 months to assess the effectiveness of these interventions in restoring their ability to sense low blood sugar levels. The goal is to identify which treatment works best for different individuals based on their specific clinical characteristics.
Why it matters
Potential benefit: If successful, this research could significantly improve the safety and quality of life for adults with type 1 diabetes by enhancing their awareness of hypoglycemia.
How similar studies have gone: Previous research has shown promising results with similar interventions aimed at improving hypoglycemia awareness in individuals with type 1 diabetes.
Where this research is happening
-
University of Sheffield
Sheffield, United Kingdom Active
Researchers
- Principal investigator: Heller, Simon Richard — University of Sheffield
- Study coordinator: Heller, Simon Richard
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
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Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
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Understanding how impaired hypoglycemia awareness develops in type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study looks at adults with type 1 diabetes who struggle to sense hypoglycemia and tests whether automated insulin delivery and exercise can help restore their awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.