Understanding how a brain receptor helps regulate low blood sugar levels
Official title: Role of Hypothalamic Adgrl1 in Counteracting Hypoglycemia
Funded at University of Kentucky · NIH-11133672 · Data updated 2026-11-12
This study is looking at how a special receptor in the brain helps control low blood sugar levels, and it's using mice to see what happens when this receptor is missing, which could help improve diabetes treatments in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | September 7, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $293,604 |
| NIH project number | 1R56DK140148-01 |
| Project ID | NIH-11133672 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes, especially those who have episodes of severe low blood sugar.
✕Less likely to help
Patients who do not have diabetes or do not experience hypoglycemia may not benefit from this research.
What this research studies
This research investigates the role of a specific receptor in the hypothalamus, known as Adgrl1, which is crucial for managing dangerously low blood sugar levels. The study aims to understand how Adgrl1 influences the brain's response to hypoglycemia and its impact on glucose balance. By using mouse models, researchers will explore how the absence of this receptor affects the body's ability to counteract low blood sugar and restore normal levels. The findings could lead to new insights into diabetes management and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals with diabetes, particularly those who experience severe hypoglycemia.
How similar studies have gone: Other research has shown promising results in understanding the role of brain receptors in glucose regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Chhabra, Kavaljit H — University of Kentucky
- Study coordinator: Chhabra, Kavaljit H
Related research
Other NIH-funded projects on the same topics.
-
Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
-
Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
-
Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
-
Glucagon Pump Therapy for PBH in People After Bariatric Surgery
A new approach uses a patch pump and smart control to deliver glucagon during meal-related lows in adults who had bariatric surgery and developed dangerous hypoglycemia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.