Research on diagnosing and treating low blood sugar levels

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on understanding the causes and treatment of hypoglycemia, particularly in patients with insulinomas. Participants will undergo fasting blood tests to evaluate their blood sugar and insulin levels, while being monitored and treated as necessary. The study aims to identify new biomarkers for insulinomas and create a clinical data repository for future research. Patients will be admitted to the Clinical Center of the National Institutes of Health for thorough evaluation and care.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Male, females ages \>= 18.
2. Patients with documented fasting blood glucose below 55 mg/dl.

4\. Patients with biochemical evidence for insulinoma or other pancreatic neuroendocrine tumors.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. Patients with significant cardiac disease will be excluded.
2. Subjects who are pregnant per self-report.
3. Medically unstable per the assessment of the PI.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Ranganath Muniyappa, M.D. — National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Study coordinator: Magaly R Donayre
• Email: magaly.donayre@nih.gov
• Phone: (202) 909-8137

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding glucagon and sugar metabolism after meals in people with and without PBH after weight-loss surgery

  This study tests how glucagon and post-meal glucose handling differ between people who have post-bariatric surgery hypoglycemia and those who don’t.

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• A new PET/CT test to find insulinoma using a GLP-1R tracer compared to an earlier tracer

  A GLP-1 receptor–targeted PET/CT imaging agent is being tested in adults with suspected or confirmed insulinoma to see if the PEG6-modified tracer locates tumors better than the original tracer.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07808879

• EUS-guided radiofrequency ablation for pancreatic insulinoma safety and effectiveness

  This project will try EUS-guided radiofrequency ablation (EUS-RFA) to treat people with pathology-confirmed pancreatic insulinoma and compare safety and outcomes to historic surgical patients.

  Recruiting Sahlgrenska University Hospital · Gothenburg · NCT07585032

• Fear of hypoglycemia in people with diabetes

  This study looks at how fear of low blood sugar affects how people with diabetes take their medications and manage their diet.

  Recruiting Bilecik Seyh Edebali Universitesi · Bilecik · NCT07329985

• How sexual activity affects low blood sugar risk in adults with insulin-treated diabetes who use a CGM

  This study will see if sexual activity changes the risk of low blood sugar in adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor.

  Recruiting Medical University of Warsaw · Warsaw · NCT07286500

• Endoscopic ultrasound-guided radiofrequency ablation for pancreatic and left adrenal lesions

  This will try EUS-guided radiofrequency ablation to control symptoms and hormone-related problems in adults with small pancreatic neuroendocrine tumors (including insulinomas) or certain left adrenal adenomas.

  Recruiting Herlev Hospital · Herlev, Capital Region · NCT07272187

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.