Using technology to improve awareness of low blood sugar in type 1 diabetes patients
Official title: Using technology to define and mitigate risk of impaired awareness of hypoglycemia in patients with type 1 diabetes
Funded at University of California, San Diego · NIH-11077196 · Data updated 2026-11-12
This study is looking to help people with type 1 diabetes who have trouble sensing when their blood sugar is low by using special monitoring technology, and it will also see if new management tools can help them regain that awareness.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 25, 2022 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $633,053 |
| NIH project number | 5U01DK135121-03 |
| Project ID | NIH-11077196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 diabetes who experience impaired awareness of hypoglycemia.
✕Less likely to help
Patients who do not have type 1 diabetes or those who do not experience issues with hypoglycemia awareness may not benefit from this research.
What this research studies
This research aims to tackle the serious issue of severe hypoglycemia in patients with type 1 diabetes by identifying those with impaired awareness of hypoglycemia (IAH) using continuous glucose monitoring (CGM) technology. The study will analyze CGM data to find metrics that correlate with IAH and diminished counterregulatory responses. Additionally, it will explore whether modern management techniques, such as hybrid closed loop systems, can help restore awareness of hypoglycemia in these patients. By enrolling 112 subjects, the research will gather critical data on hormone responses and symptoms during hypoglycemic events.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of severe hypoglycemia for patients with type 1 diabetes by improving their awareness of low blood sugar levels.
How similar studies have gone: Previous research has shown promise in using continuous glucose monitoring to improve diabetes management, indicating that this approach may yield beneficial results.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Pettus, Jeremy H — University of California, San Diego
- Study coordinator: Pettus, Jeremy H
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
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Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
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Understanding how impaired hypoglycemia awareness develops in type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study looks at adults with type 1 diabetes who struggle to sense hypoglycemia and tests whether automated insulin delivery and exercise can help restore their awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.