Restoring awareness of low blood sugar in people with type 1 diabetes
Official title: University of Minnesota Clinical Center for the Restoration of Impaired Awareness of Hypoglycemia in Type 1 Diabetes
Funded at University of Minnesota · NIH-11076623 · Data updated 2026-11-12
This study is for people with type 1 diabetes who sometimes don't notice when their blood sugar is low, and it will test a program that teaches them how to avoid low blood sugar and uses advanced insulin delivery systems to help them regain that awareness over a year.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 25, 2022 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $997,197 |
| NIH project number | 5U01DK135130-03 |
| Project ID | NIH-11076623 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type 1 diabetes who have impaired awareness of hypoglycemia.
✕Less likely to help
Patients who do not have type 1 diabetes or those who do not experience impaired awareness of hypoglycemia may not benefit from this research.
What this research studies
This research focuses on individuals with type 1 diabetes who experience impaired awareness of hypoglycemia, which can lead to confusion or unconsciousness during low blood sugar episodes. The study aims to implement a protocol that includes education on avoiding hypoglycemia and the use of advanced insulin delivery systems over a 12-month period. Participants will be enrolled in a randomized clinical trial to assess the effectiveness of these interventions in restoring awareness of low blood sugar. The research will also explore physiological factors that may influence the restoration of awareness and develop new assessment tools for identifying impaired awareness.
Why it matters
Potential benefit: If successful, this research could help individuals with type 1 diabetes regain awareness of low blood sugar, improving their safety and quality of life.
How similar studies have gone: Previous research has shown promise in using educational interventions and advanced insulin delivery systems to improve glycemic control in diabetes, suggesting potential success for this approach.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Seaquist, Elizabeth R. — University of Minnesota
- Study coordinator: Seaquist, Elizabeth R.
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
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Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
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Understanding how impaired hypoglycemia awareness develops in type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study looks at adults with type 1 diabetes who struggle to sense hypoglycemia and tests whether automated insulin delivery and exercise can help restore their awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.