Understanding how high blood sugar affects heart cells in diabetes
Official title: Hyperglycemia-induced regulatory mechanism of ER stress by arresting domain-containing protein 4 in diabetic cardiomyopathy
Funded at City College of New York · NIH-11009543 · Data updated 2026-11-12
This study is looking at how a protein called Arrdc4 affects heart cells when blood sugar levels are high, which can help us find new ways to keep hearts healthier for people with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | City College of New York NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 15, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $392,500 |
| NIH project number | 5R01HL168191-02 |
| Project ID | NIH-11009543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with diabetes who are experiencing heart-related issues.
✕Less likely to help
Patients without diabetes or those who do not have any heart complications related to diabetes may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, Arrestin Domain-Containing protein 4 (Arrdc4), in how high blood sugar levels lead to stress in heart cells, which can cause heart problems in people with diabetes. The study uses a combination of laboratory experiments and animal models to explore how Arrdc4 affects glucose uptake in heart cells and contributes to cardiac dysfunction. By understanding this mechanism, the research aims to identify potential therapeutic targets for improving heart health in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect heart function in individuals with diabetes.
How similar studies have gone: Previous research has shown that targeting cellular stress responses can improve outcomes in diabetic complications, suggesting that this approach may hold promise.
Where this research is happening
-
City College of New York
New York, United States Active
Researchers
- Principal investigator: Yoshioka, Jun — City College of New York
- Study coordinator: Yoshioka, Jun
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This research looks at whether a protein called Arrdc4 causes stress in heart cells when blood sugar is high and so helps explain heart damage in adults with diabetes.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.