How high blood sugar affects lung infections caused by bacteria
Official title: Impact of hyperglycemia on the pathogenesis of chronic bacterial lung infection
Funded at Univ of North Carolina Chapel Hill · NIH-10849775 · Data updated 2026-11-12
This study is looking at how high blood sugar levels affect lung infections caused by a specific bacteria, which can make breathing problems worse, especially for people with diabetes, to help find better ways to treat these infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $223,417 |
| NIH project number | 5R21AI174088-02 |
| Project ID | NIH-10849775 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with muco-obstructive airway diseases who also have diabetes.
✕Less likely to help
Patients without chronic lung infections or those who do not have diabetes may not benefit from this research.
What this research studies
This research investigates the impact of high blood sugar levels on chronic bacterial lung infections, particularly focusing on the bacteria Pseudomonas aeruginosa, which is known to worsen conditions like muco-obstructive airway diseases. The study aims to understand how diabetes, a common condition among patients with these lung diseases, influences the bacteria's ability to survive and resist antibiotic treatment. By using advanced laboratory models, researchers will explore the relationship between hyperglycemia and bacterial behavior, potentially leading to new treatment strategies. Patients with chronic lung infections may find this research relevant as it seeks to uncover mechanisms that could improve their care.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with chronic lung infections, particularly those with diabetes.
How similar studies have gone: Previous research has shown that understanding the interactions between diabetes and bacterial infections can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Wolfgang, Matthew C — Univ of North Carolina Chapel Hill
- Study coordinator: Wolfgang, Matthew C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.