Investigating the link between early high blood sugar and shunt dependency after brain hemorrhage
Shunt-dependency After Aneurysmal Subarachnoid Haemorrhage - the Role of Early Hyperglycaemia in Cerebro-spinal Fluid and Blood
This study is trying to see if high blood sugar levels in patients with a brain hemorrhage affect their need for a special drainage device after treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 160 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Cantonal Hospital of St. Gallen Academic / other |
| Locations | 3 sites (Aarau and 2 other locations) |
| Trial ID | NCT06486909 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between elevated glucose levels in cerebrospinal fluid (CSF) and the need for ventriculo-peritoneal shunts (VPS) in patients who have experienced an aneurysmal subarachnoid hemorrhage (aSAH). Researchers will measure glucose levels in both CSF and blood upon hospital admission and daily until the removal of an external ventricular drain (EVD). The study seeks to determine if early hyperglycemia is associated with VPS dependency and how glucose levels change over time may influence this outcome. Follow-up assessments will occur at 3 and 6 months post-treatment.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who have been admitted to the hospital due to an aneurysmal subarachnoid hemorrhage.
Not a fit: Patients with non-aneurysmal subarachnoid hemorrhage or those under 18 years old may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with aSAH, potentially reducing the need for permanent shunt placement.
How similar studies have performed: While the specific association of hyperglycemia and VPS dependency in aSAH is not widely studied, related research on glucose levels and neurological outcomes suggests potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years old and older * Hospital admission due to an aneurysmal subarachnoid haemorrhage (radiological confirmation needed) Exclusion Criteria: * Younger than 18 years old * Non-aneurysmal subarachnoid haemorrhage (eg. trauma, perimesencephalic subarachnoid haemorrhage, mycotic or flow-associated aneurysms) * Previous enrolment into the current study
Where this trial is running
Aarau and 2 other locations
- Cantonal Hospital Aarau — Aarau, Switzerland (Recruiting)
- University Hospital Basel — Basel, Switzerland (Recruiting)
- Cantonal Hospital St Gallen — Sankt Gallen, Switzerland (Recruiting)
Study contacts
- Principal investigator: Isabel Hostettler, MD PhD — Cantonal Hospital of St. Gallen
- Study coordinator: Isabel Hostettler, MD PhD
- Email: isabel.hostettler@kssg.ch
- Phone: +41 71 494 97 40
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.