Investigating the link between early high blood sugar and shunt dependency after brain hemorrhage
Official title: Shunt-dependency After Aneurysmal Subarachnoid Haemorrhage - the Role of Early Hyperglycaemia in Cerebro-spinal Fluid and Blood
Run by Cantonal Hospital of St. Gallen · NCT06486909 · Data updated 2026-11-12
This study is trying to see if high blood sugar levels in patients with a brain hemorrhage affect their need for a special drainage device after treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 160 (estimated) |
| Sponsor | Cantonal Hospital of St. Gallen Academic / other |
| Locations | 3 sites (Aarau and 2 other locations) |
| Status | Recruiting |
| Started | March 26, 2024 |
| Main results expected | March 2027 |
| Study ends | September 2028 |
| Registry record updated | March 18, 2026 |
| Trial ID | NCT06486909 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have been admitted to the hospital due to an aneurysmal subarachnoid hemorrhage.
✕Probably not a fit
Patients with non-aneurysmal subarachnoid hemorrhage or those under 18 years old may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the relationship between elevated glucose levels in cerebrospinal fluid (CSF) and the need for ventriculo-peritoneal shunts (VPS) in patients who have experienced an aneurysmal subarachnoid hemorrhage (aSAH). Researchers will measure glucose levels in both CSF and blood upon hospital admission and daily until the removal of an external ventricular drain (EVD). The study seeks to determine if early hyperglycemia is associated with VPS dependency and how glucose levels change over time may influence this outcome. Follow-up assessments will occur at 3 and 6 months post-treatment.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with aSAH, potentially reducing the need for permanent shunt placement.
How similar studies have gone: While the specific association of hyperglycemia and VPS dependency in aSAH is not widely studied, related research on glucose levels and neurological outcomes suggests potential for meaningful insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years old and older * Hospital admission due to an aneurysmal subarachnoid haemorrhage (radiological confirmation needed) Exclusion Criteria: * Younger than 18 years old * Non-aneurysmal subarachnoid haemorrhage (eg. trauma, perimesencephalic subarachnoid haemorrhage, mycotic or flow-associated aneurysms) * Previous enrolment into the current study
Where it's running
-
Cantonal Hospital Aarau
Aarau, Switzerland Recruiting -
University Hospital Basel
Basel, Switzerland Recruiting -
Cantonal Hospital St Gallen
Sankt Gallen, Switzerland Recruiting
Study contacts
- Principal investigator: Isabel Hostettler, MD PhD — Cantonal Hospital of St. Gallen
- Study coordinator: Isabel Hostettler, MD PhD
- Email: isabel.hostettler@kssg.ch
- Phone: +41 71 494 97 40
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.